Redefining the Protein-Protein Interface : Coarse Graining and Combinatorics for an Improved Understanding of Amino Acid Contributions to the Protein-Protein Binding Affinity
The ability to intervene in biological pathways has for decades been limited by the lack of a quantitative description of protein-protein interactions (PPIs). Herein we generate and compare millions of simple PPI models for insight into the mechanisms of specific recognition and binding. We use a co...
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