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cr uuu---uuuuu |
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231225s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.08.012
|2 doi
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|a pubmed24n1223.xml
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|a (DE-627)NLM275174336
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|a (NLM)28844702
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|a (PII)S1521-6616(17)30160-2
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Ding, Quanquan
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Ficolin-2 triggers antitumor effect by activating macrophages and CD8+ T cells
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| 264 |
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1 |
|c 2017
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 21.11.2017
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| 500 |
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|a Date Revised 13.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a Ficolin-2 is an important serum complement lectin. Here, we describe novel findings indicating that serum ficolin-2 concentrations in multiple tumor patients are significantly lower than those in healthy donors. Administration of exogenous ficolin-2 or ficolin-A (a ficolin-2-like molecule in mouse), with only once, could remarkably inhibit the tumor cells growth in murine tumor models via early macrophages, dendritic cells (DCs) and CD8+ T cells, but not CD4+ T cells. Ficolin-A (FCN-A) knockout (KO) mice exhibits significantly increased tumor cell growth. Ficolin-2 induces macrophage activation, promotes M1 polarization and facilitates proliferation and antigen-specific cytotoxicity of CD8+ T cells. Ficolin-2 binds to Toll-like receptor 4 (TLR4) on macrophages and DCs and promotes their antigen-presenting abilities to CD8+ T cells. Our findings provide a new therapeutic strategy for tumors based on the triggering of immune-mediated antitumor effect by ficolin-2
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antitumor effect
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|a CD8(+) T
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| 650 |
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|a Dendritic cells (DCs)
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|a Ficolin-2/A
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| 650 |
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4 |
|a Macrophage
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| 650 |
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|a Ccl5 protein, mouse
|2 NLM
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| 650 |
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|a Chemokine CCL5
|2 NLM
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| 650 |
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|a Interleukin-6
|2 NLM
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| 650 |
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|a Lectins
|2 NLM
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| 650 |
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|a Tlr4 protein, mouse
|2 NLM
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| 650 |
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|a Toll-Like Receptor 4
|2 NLM
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| 650 |
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|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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|a interleukin-6, mouse
|2 NLM
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| 650 |
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|a Nitric Oxide
|2 NLM
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| 650 |
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7 |
|a 31C4KY9ESH
|2 NLM
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| 700 |
1 |
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|a Shen, Yanying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Dongqing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Juan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yu, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yin, Zhinan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xiao-Lian
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 183(2017) vom: 01. Okt., Seite 145-157
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:183
|g year:2017
|g day:01
|g month:10
|g pages:145-157
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2017.08.012
|3 Volltext
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