Immunometabolic profiling of patients with multiple sclerosis identifies new biomarkers to predict disease activity during treatment with interferon beta-1a

Copyright © 2017 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 183(2017) vom: 15. Okt., Seite 249-253
1. Verfasser: Lanzillo, Roberta (VerfasserIn)
Weitere Verfasser: Carbone, Fortunata, Quarantelli, Mario, Bruzzese, Dario, Carotenuto, Antonio, De Rosa, Veronica, Colamatteo, Alessandra, Micillo, Teresa, De Luca Picione, Carla, Saccà, Francesco, De Rosa, Anna, Moccia, Marcello, Brescia Morra, Vincenzo, Matarese, Giuseppe
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Autoimmunity IFN-beta-1a IL-6 Leptin Adjuvants, Immunologic Biomarkers Interferon beta-1a XRO4566Q4R
LEADER 01000naa a22002652 4500
001 NLM274970422
003 DE-627
005 20231225004632.0
007 cr uuu---uuuuu
008 231225s2017 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.clim.2017.08.011  |2 doi 
028 5 2 |a pubmed24n0916.xml 
035 |a (DE-627)NLM274970422 
035 |a (NLM)28823971 
035 |a (PII)S1521-6616(17)30257-7 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Lanzillo, Roberta  |e verfasserin  |4 aut 
245 1 0 |a Immunometabolic profiling of patients with multiple sclerosis identifies new biomarkers to predict disease activity during treatment with interferon beta-1a 
264 1 |c 2017 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 13.12.2017 
500 |a Date Revised 06.02.2018 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2017 Elsevier Inc. All rights reserved. 
520 |a Reliable immunologic biomarkers able to monitor disease course during multiple sclerosis (MS) are still missing. We aimed at identifying possible immunometabolic biomarkers able to predict the clinical outcome in MS patients during treatment with interferon (IFN)-beta-1a. We measured in 45 relapsing-remitting (RR) MS patients, blood circulating levels of several immunometabolic markers, at enrolment, and correlated their levels to disease activity and progression over time. Higher levels of interleukin (IL)-6, soluble-CD40-ligand (sCD40L) and leptin at baseline associated with a higher relapse rate and a greater risk of experiencing at least one relapse in the following year. Higher values of soluble tumor necrosis factor receptor (sTNF-R) and leptin at baseline were predictive of a higher number of lesions in the following one-year of follow up. In conclusion, our data suggest that an immunometabolic profiling measuring IL-6, sCD40L, leptin and sTNF-R at baseline, could represent a useful tool to predict disease course in RRMS patients during treatment with IFN-beta-1a 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Autoimmunity 
650 4 |a IFN-beta-1a 
650 4 |a IL-6 
650 4 |a Leptin 
650 7 |a Adjuvants, Immunologic  |2 NLM 
650 7 |a Biomarkers  |2 NLM 
650 7 |a Interferon beta-1a  |2 NLM 
650 7 |a XRO4566Q4R  |2 NLM 
700 1 |a Carbone, Fortunata  |e verfasserin  |4 aut 
700 1 |a Quarantelli, Mario  |e verfasserin  |4 aut 
700 1 |a Bruzzese, Dario  |e verfasserin  |4 aut 
700 1 |a Carotenuto, Antonio  |e verfasserin  |4 aut 
700 1 |a De Rosa, Veronica  |e verfasserin  |4 aut 
700 1 |a Colamatteo, Alessandra  |e verfasserin  |4 aut 
700 1 |a Micillo, Teresa  |e verfasserin  |4 aut 
700 1 |a De Luca Picione, Carla  |e verfasserin  |4 aut 
700 1 |a Saccà, Francesco  |e verfasserin  |4 aut 
700 1 |a De Rosa, Anna  |e verfasserin  |4 aut 
700 1 |a Moccia, Marcello  |e verfasserin  |4 aut 
700 1 |a Brescia Morra, Vincenzo  |e verfasserin  |4 aut 
700 1 |a Matarese, Giuseppe  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 183(2017) vom: 15. Okt., Seite 249-253  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:183  |g year:2017  |g day:15  |g month:10  |g pages:249-253 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2017.08.011  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_11 
912 |a GBV_ILN_24 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 183  |j 2017  |b 15  |c 10  |h 249-253