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231225s2017 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.7b02488
|2 doi
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|a pubmed24n0915.xml
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|a (DE-627)NLM274768690
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|a (NLM)28803471
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Wang, Meizhe
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Altering the Peptide Binding Selectivity of Polymeric Reverse Micelle Assemblies via Metal Ion Loading
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 18.01.2019
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|a Date Revised 18.01.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Supramolecular reverse micelle assemblies, formed by amphiphilic copolymers, can selectively encapsulate molecules in their interiors depending on the functional groups present in the polymers. Altering the binding selectivity of these materials typically requires the synthesis of alternate functional groups. Here, we demonstrate that the addition of Zr(IV) ions to the interiors of reverse micelles having phosphonate functional groups transforms the supramolecular materials from ones that selectively bind positively charged peptides into materials that selectively bind phosphorylated peptides. We also show that the binding selectivity of these reverse micelle assemblies can be further tuned by varying the fractions of phosphonate groups in the copolymer structure. The optimized reverse micelle materials can selectively transfer and bind phosphorylated peptides from aqueous solutions over a wide range of pH conditions and can selectively enrich phosphorylated peptides even in complicated mixtures
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Ions
|2 NLM
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|a Metals
|2 NLM
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|a Micelles
|2 NLM
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|a Peptides
|2 NLM
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|a Polymers
|2 NLM
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| 700 |
1 |
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|a Zhao, Bo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Jingjing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Huan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Castellanos, Laura J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Thayumanavan, S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vachet, Richard W
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 33(2017), 49 vom: 12. Dez., Seite 14004-14010
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:33
|g year:2017
|g number:49
|g day:12
|g month:12
|g pages:14004-14010
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|u http://dx.doi.org/10.1021/acs.langmuir.7b02488
|3 Volltext
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