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231225s2017 xx |||||o 00| ||eng c |
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|a 10.1111/vcp.12530
|2 doi
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|a pubmed25n0914.xml
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|a (NLM)28750148
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Paltrinieri, Saverio
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Analytic variability in the enumeration of neutrophil subpopulations in canine blood
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1 |
|c 2017
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 31.07.2018
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|a Date Revised 10.12.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2017 American Society for Veterinary Clinical Pathology.
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|a BACKGROUND: Conventional differential leukocyte counts do not enumerate hyposegmented neutrophils (Hypo-PMN), ie, immature neutrophils that already lost the band morphology but are not yet completely segmented. They may be early indicators of acute inflammation
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|a OBJECTIVES: The purpose of the study was to evaluate the analytic variability of counts of segmented neutrophils (Seg-PMN), band neutrophils (Band), hyposegmented neutrophils (Hypo-PMN), non-Bands (Hypo-PMN + Seg-PMN), and Young-PMN (Bands + Hypo-PMN) assess if Hypo- or Young-PMN identify inflammation better than Bands
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|a METHODS: Neutrophil subpopulations were counted by 2 observers on 2 sets of 100 cells in 267 blood smears from dogs with changes potentially consistent with inflammation to calculate the intra- and inter-observer variability
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|a RESULTS: Median intra-observer CVs were < 5.0% for Seg-PMN and non-Bands, and 20.0% and 28.0% for Hypo-PMN and Young-PMN for observer 1 and 2, respectively; median inter-observer CVs for Seg-PMN, non-Bands, Hypo-PMN, and Young-PMN were 4.6%, 5.0%, 60.0%, and 47.1%, respectively. Median CV of Band counts in blood smears with bands was 141%
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|a CONCLUSIONS: The analytic variability of Hypo- and Young-PMN is lower than that of Bands. This retrospective study did not allow us to investigate the diagnostic potential or the clinical relevance of these cells. However, the low inter- and intra-observer variabilities with these cell populations suggest that the count of Hypo- or Young-PMN may better identify acute inflammation than the count of Bands
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|a Evaluation Study
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|a Journal Article
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|a Dog
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|a inflammation
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|a left shift
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|a leukogram
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| 650 |
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4 |
|a neutrophilia
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| 700 |
1 |
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|a Talon, Elisa
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 46(2017), 4 vom: 21. Dez., Seite 551-557
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnas
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| 773 |
1 |
8 |
|g volume:46
|g year:2017
|g number:4
|g day:21
|g month:12
|g pages:551-557
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| 856 |
4 |
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|u http://dx.doi.org/10.1111/vcp.12530
|3 Volltext
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