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231225s2017 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201701266
|2 doi
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|a pubmed24n0914.xml
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|a (DE-627)NLM274200694
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|a (NLM)28745411
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Deng, Xiaoran
|e verfasserin
|4 aut
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| 245 |
1 |
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|a A Hollow-Structured CuS@Cu2 S@Au Nanohybrid
|b Synergistically Enhanced Photothermal Efficiency and Photoswitchable Targeting Effect for Cancer Theranostics
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 22.01.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a It is of great importance in drug delivery to fabricate multifunctional nanocarriers with intelligent targeting properties, for cancer diagnosis and therapy. Herein, hollow-structured CuSCu2 S@Au nanoshell/satellite nanoparticles are designed and synthesized for enhanced photothermal therapy and photoswitchable targeting theranostics. The remarkably improved photothermal conversion efficiency of CuS@Cu2 S@Au under 808 nm near-infrared (NIR) laser irradiation can be explained by the reduced bandgap and more circuit paths for electron transitions for CuS and Cu2 S modified with Au nanoparticles, as calculated by the Vienna ab initio simulation package, based on density functional theory. By modification of thermal-isomerization RGD targeting molecules and thermally sensitive copolymer on the surface of nanoparticles, the transition of the shielded/unshielded mode of RGD (Arg-Gly-Asp) targeting molecules and shrinking of the thermally sensitive polymer by NIR photoactivation can realize a photoswitchable targeting effect. After loading an anticancer drug doxorubicin in the cavity of CuS@Cu2 S@Au, the antitumor therapy efficacy is greatly enhanced by combining chemo- and photothermal therapy. The reported nanohybrid can also act as a photoacoustic imaging agent and an NIR thermal imaging agent for real-time imaging, which provides a versatile platform for multifunctional theranostics and stimuli-responsive targeted cancer therapy
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|a Journal Article
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|a HCuS@Cu2S@Au
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|a cancer therapy
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|a enhanced photothermal efficiency
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|a photoswitchable targeting effect
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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|a Copper
|2 NLM
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|a 789U1901C5
|2 NLM
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|a Doxorubicin
|2 NLM
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|a 80168379AG
|2 NLM
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|a cupric sulfide
|2 NLM
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| 650 |
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|a KL4YU612X7
|2 NLM
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| 700 |
1 |
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|a Li, Kai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cai, Xuechao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Bin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wei, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deng, Kerong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Zhongxi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Zhijian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Ping'an
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hou, Zhiyao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Ziyong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Jun
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 29(2017), 36 vom: 10. Sept.
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:29
|g year:2017
|g number:36
|g day:10
|g month:09
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201701266
|3 Volltext
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|d 29
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|e 36
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