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231225s2017 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1002/adma.201701545
|2 doi
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5 |
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|a pubmed25n0913.xml
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|a (DE-627)NLM274062909
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|a (NLM)28731273
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Weng, Yu-Shih
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Scaffold-Free Liver-On-A-Chip with Multiscale Organotypic Cultures
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 18.07.2018
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a The considerable advances that have been made in the development of organotypic cultures have failed to overcome the challenges of expressing tissue-specific functions and complexities, especially for organs that require multitasking and complex biological processes, such as the liver. Primary liver cells are ideal biological building blocks for functional organotypic reconstruction, but are limited by their rapid loss of physiological integrity in vitro. Here the concept of lattice growth used in material science is applied to develop a tissue incubator, which provides physiological cues and controls the 3D assembly of primary cells. The cues include a biological growing template, spatial coculture, biomimetic radial flow, and circulation in a scaffold-free condition. The feasibility of recapitulating a multiscale physiological structural hierarchy, complex drug clearance, and zonal physiology from the cell to tissue level in long-term cultured liver-on-a-chip is demonstrated. These methods are promising for future applications in pharmacodynamics and personal medicine
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|a Journal Article
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|a biomimetic radial flow
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4 |
|a liver-on-a-chip (LOC)
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| 650 |
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4 |
|a scaffold-free fabrication
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| 650 |
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4 |
|a spatial coculture
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| 700 |
1 |
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|a Chang, Shau-Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shih, Ming-Cheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tseng, Shih-Heng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lai, Chih-Huang
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 29(2017), 36 vom: 21. Sept.
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:29
|g year:2017
|g number:36
|g day:21
|g month:09
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|u http://dx.doi.org/10.1002/adma.201701545
|3 Volltext
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