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231225s2018 xx |||||o 00| ||eng c |
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|a 10.5713/ajas.17.0218
|2 doi
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|a pubmed24n0913.xml
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|a (DE-627)NLM274034247
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|a (NLM)28728355
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Won, Sohyoung
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Identification of genes related to intramuscular fat content of pigs using genome-wide association study
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|c 2018
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Revised 01.10.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a OBJECTIVE: The aim of this study is to identify single nucleotide polymorphisms (SNPs) and genes related to pig IMF and estimate the heritability of intramuscular fat content (IMF)
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|a METHODS: Genome-wide association study (GWAS) on 704 inbred Berkshires was performed for IMF. To consider the inbreeding among samples, associations of the SNPs with IMF were tested as random effects in a mixed linear model using the genetic relationship matrix by GEMMA. Significant genes were compared with reported pig IMF quantitative trait loci (QTL) regions and functional classification of the identified genes were also performed. Heritability of IMF was estimated by GCTA tool
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|a RESULTS: Total 365 SNPs were found to be significant from a cutoff of p-value <0.01 and the 365 significant SNPs were annotated across 120 genes. Twenty five genes were on pig IMF QTL regions. Bone morphogenetic protein-binding endothelial cell precursor-derived regulator, forkhead box protein O1, ectodysplasin A receptor, ring finger protein 149, cluster of differentiation, tyrosine-protein phosphatase non-receptor type 1, SRY (sex determining region Y)-box 9 (SOX9), MYC proto-oncogene, and macrophage migration inhibitory factor were related to mitogen-activated protein kinase pathway, which regulates the differentiation to adipocytes. These genes and the genes mapped on QTLs could be the candidate genes affecting IMF. Heritability of IMF was estimated as 0.52, which was relatively high, suggesting that a considerable portion of the total variance of IMF is explained by the SNP information
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|a CONCLUSION: Our results can contribute to breeding pigs with better IMF and therefore, producing pork with better sensory qualities
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|a Journal Article
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|a Genome-wide Association Study
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| 650 |
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|a Heritability
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| 650 |
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|a Intramuscular Fat Content
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| 650 |
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4 |
|a Pig
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| 650 |
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4 |
|a Single Nucleotide Polymorphisms
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| 700 |
1 |
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|a Jung, Jaehoon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Park, Eungwoo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, Heebal
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Asian-Australasian journal of animal sciences
|d 1998
|g 31(2018), 2 vom: 25. Feb., Seite 157-162
|w (DE-627)NLM098195883
|x 1011-2367
|7 nnns
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| 773 |
1 |
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|g volume:31
|g year:2018
|g number:2
|g day:25
|g month:02
|g pages:157-162
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|u http://dx.doi.org/10.5713/ajas.17.0218
|3 Volltext
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