Photothermal Ring Integrated Intraocular Lens for High-Efficient Eye Disease Treatment

Photothermal Ring Integrated Intraocular Lens for High-Efficient Eye Disease Treatment

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 29(2017), 34 vom: 27. Sept.
1. Verfasser: Lin, Yao-Xin (VerfasserIn)
Weitere Verfasser: Hu, Xue-Feng, Zhao, Yang, Gao, Yu-Juan, Yang, Chao, Qiao, Sheng-Lin, Wang, Yi, Yang, Pei-Pei, Yan, Jiao, Sui, Xin-Ce, Qiao, Zeng-Ying, Li, Li-Li, Xie, Jiang-Bing, Zhu, Si-Quan, Wu, Xiao-Chun, Li, Yongsheng, Wang, Lei, Wang, Hao
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article gold nanorods nanoparticles photothermal posterior capsule opacification Acrylic Resins Silicon Dioxide 7631-86-9
Beschreibung
Zusammenfassung:© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Posterior capsule opacification (PCO) is the most common complication after cataract surgery. So far, the only method for PCO treatment is the precisely focused laser surgery. However, it causes severe complications such as physical damages and neuron impairments. Here, a nanostructured photothermal ring integrated intraocular lens (Nano-IOLs) is reported, in which the rim of commercially available IOLs (C-IOLs) is decorated with silica coated Au nanorods (AuSiO2 ), for high-efficient prevention of PCO after cataract surgery. The Nano-IOLs is capable of eliminating the residual lens epithelial cells (LECs) around Nano-IOLs under mild laser treatment and block the formation of disordered LECs fibrosis, which eventually leads to the loss of vision. The Nano-IOLs shows good biocompatibility as well as extraordinary region-confined photothermal effect. In vivo studies reveal that PCO occurrence in rabbit models is about 30%-40% by using Nano-IOLs, which is significantly lower than the control group that treated with C-IOLs (100% PCO occurrence) 30 d postsurgery. To the best of our knowledge, it is the first example to integrate nanotechnology with intraocular implants aiming to clinically relevant PCO. Our findings indicate that spatial controllability of photothermal effect from nanomaterials may provide a unique way to intervene the PCO-induced loss of vision
Beschreibung:Date Completed 22.01.2019
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201701617