Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2 Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues

Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2 Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 29(2017), 34 vom: 01. Sept.
1. Verfasser: Du, Jiangfeng (VerfasserIn)
Weitere Verfasser: Gu, Zhanjun, Yan, Liang, Yong, Yuan, Yi, Xuan, Zhang, Xiao, Liu, Jing, Wu, Renfei, Ge, Cuicui, Chen, Chunying, Zhao, Yuliang
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Bi2Se3 nanoparticles immunity radiation side-effects selenocysteine synergistic therapies Organoselenium Compounds Polyvinyls Pyrrolidinones Radiation-Sensitizing Agents mehr... Selenium Compounds Selenocysteine 0CH9049VIS bismuth selenide 9I1Y040903 Bismuth U015TT5I8H
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024 7 |a 10.1002/adma.201701268  |2 doi 
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100 1 |a Du, Jiangfeng  |e verfasserin  |4 aut 
245 1 0 |a Poly(Vinylpyrollidone)- and Selenocysteine-Modified Bi2 Se3 Nanoparticles Enhance Radiotherapy Efficacy in Tumors and Promote Radioprotection in Normal Tissues 
264 1 |c 2017 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
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500 |a Date Completed 22.01.2019 
500 |a Date Revised 04.12.2021 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 
520 |a The development of a new generation of nanoscaled radiosensitizers that can not only enhance radiosensitization of tumor tissues, but also increase radioresistance of healthy tissue is highly desirable, but remains a great challenge. Here, this paper reports a new versatile theranostics based on poly(vinylpyrollidone)- and selenocysteine-modified Bi2 Se3 nanoparicles (PVP-Bi2 Se3 Sec NPs) for simultaneously enhancing radiotherapeutic effects and reducing the side-effects of radiation. The as-prepared nanoparticles exhibit significantly enhanced free-radical generation upon X-ray radiation, and remarkable photothermal effects under 808 nm NIR laser irradiation because of their strong X-ray attenuation ability and high NIR absorption capability. Moreover, these PVP-Bi2 Se3 @Sec NPs are biodegradable. In vivo, part of selenium can be released from NPs and enter the blood circulation system, which can enhance the immune function and reduce the side-effects of radiation in the whole body. As a consequence, improved superoxide dismutase and glutathione peroxidase activities, promoted secretion of cytokines, increased number of white blood cell, and reduced marrow DNA suppression are found after radiation treatment in vivo. Moreover, there is no significant in vitro and in vivo toxicity of PVP-Bi2 Se3 @Sec NPs during the treatment, which demonstrates that PVP-Bi2 Se3 @Sec NPs have good biocompatibility 
650 4 |a Journal Article 
650 4 |a Bi2Se3 nanoparticles 
650 4 |a immunity 
650 4 |a radiation side-effects 
650 4 |a selenocysteine 
650 4 |a synergistic therapies 
650 7 |a Organoselenium Compounds  |2 NLM 
650 7 |a Polyvinyls  |2 NLM 
650 7 |a Pyrrolidinones  |2 NLM 
650 7 |a Radiation-Sensitizing Agents  |2 NLM 
650 7 |a Selenium Compounds  |2 NLM 
650 7 |a Selenocysteine  |2 NLM 
650 7 |a 0CH9049VIS  |2 NLM 
650 7 |a bismuth selenide  |2 NLM 
650 7 |a 9I1Y040903  |2 NLM 
650 7 |a Bismuth  |2 NLM 
650 7 |a U015TT5I8H  |2 NLM 
700 1 |a Gu, Zhanjun  |e verfasserin  |4 aut 
700 1 |a Yan, Liang  |e verfasserin  |4 aut 
700 1 |a Yong, Yuan  |e verfasserin  |4 aut 
700 1 |a Yi, Xuan  |e verfasserin  |4 aut 
700 1 |a Zhang, Xiao  |e verfasserin  |4 aut 
700 1 |a Liu, Jing  |e verfasserin  |4 aut 
700 1 |a Wu, Renfei  |e verfasserin  |4 aut 
700 1 |a Ge, Cuicui  |e verfasserin  |4 aut 
700 1 |a Chen, Chunying  |e verfasserin  |4 aut 
700 1 |a Zhao, Yuliang  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 29(2017), 34 vom: 01. Sept.  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnns 
773 1 8 |g volume:29  |g year:2017  |g number:34  |g day:01  |g month:09 
856 4 0 |u http://dx.doi.org/10.1002/adma.201701268  |3 Volltext 
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