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231225s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.07.004
|2 doi
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|a pubmed25n0912.xml
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|a (PII)S1521-6616(17)30298-X
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|e rakwb
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|a eng
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| 100 |
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|a Xu, Bihua
|e verfasserin
|4 aut
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|a The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 21.11.2017
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE remains unclear. The frequency of circulating Tfr and Tfh cells were examined in SLE patients and healthy controls. The frequency of circulating Tfr cell decreased and Tfh/Tfr ratio increased in SLE patients. Serum anti-dsDNA antibody level positively correlated with frequency of Tfh cells and Tfh/Tfr ratios but negatively correlated with the frequency of Tfr cells. Moreover, the frequency of Tfr and Tfh/Tfr ratio but not that of Tfh was correlated with diseases activity. In addition, increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were observed with successful treatments. Thus, Tfr cells should be considered as a biomarker for SLE and their role in the pathogenesis of SLE warrants further investigation
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Biomarker
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|a SLE
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|a Tfh
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|a Tfr
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|a Antibodies, Antinuclear
|2 NLM
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|a Antirheumatic Agents
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|a Glucocorticoids
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|a Immunosuppressive Agents
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|a Hydroxychloroquine
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|a 4QWG6N8QKH
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|a Cyclophosphamide
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|a 8N3DW7272P
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|a DNA
|2 NLM
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|a 9007-49-2
|2 NLM
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| 700 |
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|a Wang, Shuang
|e verfasserin
|4 aut
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|a Zhou, Mianjing
|e verfasserin
|4 aut
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| 700 |
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|a Huang, Yuefang
|e verfasserin
|4 aut
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| 700 |
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|a Fu, Rong
|e verfasserin
|4 aut
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| 700 |
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|a Guo, Chaohuan
|e verfasserin
|4 aut
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| 700 |
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|a Chen, Jingxian
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, Jijun
|e verfasserin
|4 aut
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| 700 |
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|a Gaskin, Felicia
|e verfasserin
|4 aut
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| 700 |
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|a Fu, Shu Man
|e verfasserin
|4 aut
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| 700 |
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|a Yang, Niansheng
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 183(2017) vom: 30. Okt., Seite 46-53
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:183
|g year:2017
|g day:30
|g month:10
|g pages:46-53
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|u http://dx.doi.org/10.1016/j.clim.2017.07.004
|3 Volltext
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