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231225s2017 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201701733
|2 doi
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|a pubmed24n0912.xml
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|a (DE-627)NLM273831623
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|a (NLM)28707332
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Liu, Shenghua
|e verfasserin
|4 aut
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| 245 |
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|a Conjugated Polymer for Voltage-Controlled Release of Molecules
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 22.01.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Conjugated polymers are attractive in numerous biological applications because they are flexible, biocompatible, cost-effective, solution-processable, and electronic/ionic conductive. One interesting application is for controllable drug release, and this has been realized previously using organic electronic ion pumps. However, organic electronic ion pumps show high operating voltages and limited transportation efficiency. Here, the first report of low-voltage-controlled molecular release with a novel organic device based on a conjugated polymer poly(3-hexylthiophene) is presented. The releasing rate of molecules can be accurately controlled by the duration of the voltage applied on the device. The use of a handy mobile phone to remotely control the releasing process and its application in delivering an anticancer drug to treat cancer cells are also successfully demonstrated. The working mechanism of the device is attributed to the unique switchable permeability of poly(3-hexylthiophene) in aqueous solutions under a bias voltage that can tune the wettability of poly(3-hexylthiophene) via oxidation or reduction processes. The organic devices are expected to find many promising applications for controllable drug delivery in biological systems
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|a Journal Article
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|a conjugated polymers
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|a controlled release
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|a organic bioelectronics
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4 |
|a organic semiconductors
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4 |
|a tunable wettability
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7 |
|a Delayed-Action Preparations
|2 NLM
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7 |
|a Ions
|2 NLM
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|a Polymers
|2 NLM
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| 700 |
1 |
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|a Fu, Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Guijun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Law, Helen Ka-Wai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xianfeng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yan, Feng
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 29(2017), 35 vom: 01. Sept.
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:29
|g year:2017
|g number:35
|g day:01
|g month:09
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|u http://dx.doi.org/10.1002/adma.201701733
|3 Volltext
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