|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM273052500 |
| 003 |
DE-627 |
| 005 |
20231225000243.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2017 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.201700487
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0910.xml
|
| 035 |
|
|
|a (DE-627)NLM273052500
|
| 035 |
|
|
|a (NLM)28626897
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Yang, Tao
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Ultrastable Near-Infrared Conjugated-Polymer Nanoparticles for Dually Photoactive Tumor Inhibition
|
| 264 |
|
1 |
|c 2017
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 15.01.2019
|
| 500 |
|
|
|a Date Revised 30.09.2020
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
|
| 520 |
|
|
|a It is highly desired that satisfactory photoactive agents with ideal photophysical characteristics are explored for potent cancer phototherapeutics. Herein, bifunctional nanoparticles of low-bandgap donor-acceptor (D-A)-type conjugated-polymer nanoparticles (CP-NPs) are developed to afford a highly efficient singlet-to-triplet transition and photothermal conversion for near-infrared (NIR) light-induced photodynamic (PDT)/photothermal (PTT) treatment. CP-NPs display remarkable NIR absorption with the peak at 782 nm, and perfect resistance to photobleaching. Photoexcited CP-NPs undergo singlet-to-triplet intersystem crossing through charge transfer in the excited D-A system and simultaneous nonradiative decay from the electron-deficient electron acceptor isoindigo derivative under single-wavelength NIR light irradiation, leading to distinct singlet oxygen quantum yield and high photothermal conversion efficiency. Moreover, the CP-NPs display effective cellular uptake and cytoplasmic translocation from lysosomes, as well as effective tumor accumulation, thus promoting severe light-triggered damage caused by favorable reactive oxygen species (ROS) generation and potent hyperthermia. Thus, CP-NPs achieve photoactive cell damage through their photoconversion ability for synergistic PDT/PTT treatment with tumor ablation. The proof-of-concept design of D-A-type conjugated-polymer nanoparticles with ideal photophysical characteristics provides a general approach to afford potent photoactive cancer therapy
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a nanoparticle
|
| 650 |
|
4 |
|a photoactive polymer
|
| 650 |
|
4 |
|a photodynamic therapy
|
| 650 |
|
4 |
|a photothermal therapy
|
| 650 |
|
4 |
|a tumor ablation
|
| 650 |
|
7 |
|a Polymers
|2 NLM
|
| 700 |
1 |
|
|a Liu, Ling
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Deng, Yibin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Guo, Zhengqing
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Guobing
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ge, Zhishen
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ke, Hengte
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Huabing
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 29(2017), 31 vom: 15. Aug.
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
|
| 773 |
1 |
8 |
|g volume:29
|g year:2017
|g number:31
|g day:15
|g month:08
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.201700487
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 29
|j 2017
|e 31
|b 15
|c 08
|