A Coating-Free Nonfouling Polymeric Elastomer

Bibliographische Detailangaben
Veröffentlicht in:	Advanced materials (Deerfield Beach, Fla.). - 1998. - 29(2017), 31 vom: 01. Aug.
1. Verfasser:	Hung, Hsiang-Chieh (VerfasserIn)
Weitere Verfasser:	Jain, Priyesh, Zhang, Peng, Sun, Fang, Sinclair, Andrew, Bai, Tao, Li, Bowen, Wu, Kan, Tsao, Caroline, Liu, Erik J, Sundaram, Harihara S, Lin, Xiaojie, Farahani, Payam, Fujihara, Timothy, Jiang, Shaoyi
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2017
Zugriff auf das übergeordnete Werk:	Advanced materials (Deerfield Beach, Fla.)
Schlagworte:	Journal Article coating-free elastomers nonfouling zwitterionic

Beschreibung
Zusammenfassung:	© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Medical devices face nonspecific biofouling from proteins, cells, and microorganisms, which significantly contributes to complications and device failure. Imparting these devices with nonfouling capabilities remains a major challenge, particularly for those made from elastomeric polymers. Current strategies, including surface coating and copolymerization/physical blending, necessitate compromise among nonfouling properties, durability, and mechanical strength. Here, a new strategy is reported to achieve both high bulk mechanical strength and excellent surface nonfouling properties, which are typically contradictory, in one material. This is realized through a nonfouling polymeric elastomer based on zwitterionic polycarboxybetaine derivatives. By hiding both charged moieties of the zwitterionic compounds with hydrocarbon ester and tertiary amine groups, the bulk polymer itself is elastomeric and hydrophobic while its superhydrophilic surface properties are restored upon hydrolysis. This coating-free nonfouling elastomer is a highly promising biomaterial for biomedical and engineering applications
Beschreibung:	Date Completed 18.07.2018 Date Revised 01.10.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE
ISSN:	1521-4095
DOI:	10.1002/adma.201700617