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231224s2017 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1002/adma.201701076
|2 doi
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|a pubmed25n0907.xml
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|a (DE-627)NLM272372536
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|a (NLM)28556297
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Gu, Bobo
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Precise Two-Photon Photodynamic Therapy using an Efficient Photosensitizer with Aggregation-Induced Emission Characteristics
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 12.12.2018
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Two-photon photodynamic therapy (PDT) is able to offer precise 3D manipulation of treatment volumes, providing a target level that is unattainable with current therapeutic techniques. The advancement of this technique is greatly hampered by the availability of photosensitizers with large two-photon absorption (TPA) cross section, high reactive-oxygen-species (ROS) generation efficiency, and bright two-photon fluorescence. Here, an effective photosensitizer with aggregation-induced emission (AIE) characteristics is synthesized, characterized, and encapsulated into an amphiphilic block copolymer to form organic dots for two-photon PDT applications. The AIE dots possess large TPA cross section, high ROS generation efficiency, and excellent photostability and biocompatibility, which overcomes the limitations of many conventional two-photon photosensitizers. Outstanding therapeutic performance of the AIE dots in two-photon PDT is demonstrated using in vitro cancer cell ablation and in vivo brain-blood-vessel closure as examples. This shows therapy precision up to 5 µm under two-photon excitation
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|a Journal Article
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4 |
|a aggregation-induced emission
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4 |
|a brain-blood-vessel closure
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4 |
|a cancer cells
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4 |
|a photodynamic therapy
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| 650 |
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4 |
|a two-photon excitation
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7 |
|a Biocompatible Materials
|2 NLM
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| 650 |
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|a Fluoresceins
|2 NLM
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| 650 |
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|a Photosensitizing Agents
|2 NLM
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| 650 |
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7 |
|a Polymers
|2 NLM
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| 650 |
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7 |
|a Reactive Oxygen Species
|2 NLM
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| 650 |
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7 |
|a diacetylfluorescein
|2 NLM
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| 650 |
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7 |
|a YL39R93PRE
|2 NLM
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| 700 |
1 |
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|a Wu, Wenbo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Gaixia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feng, Guangxue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yin, Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chong, Peter Han Joo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qu, Junle
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yong, Ken-Tye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Bin
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 29(2017), 28 vom: 15. Juli
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:29
|g year:2017
|g number:28
|g day:15
|g month:07
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201701076
|3 Volltext
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|d 29
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