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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.05.017
|2 doi
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|a pubmed24n0907.xml
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|a (DE-627)NLM272179582
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|a (NLM)28536054
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|a (PII)S1521-6616(17)30294-2
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Mrad, May F
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Effect of vitamin D replacement on immunological biomarkers in patients with multiple sclerosis
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 28.08.2017
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|a Date Revised 13.08.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a We aimed to investigate the immunologic effects of vitamin D replacement in RRMS patients. In a controlled single center study, patients deficient in 25-hydroxyvitamin D (serum level<25ng/ml) received 10,000IU/week cholecalciferol for 3months. Sufficient vitamin D patients (serum level>35ng/ml) were followed for the same period. Assessments were performed at baseline and at 3months. 25-hydroxyvitamin D levels increased significantly from baseline to month-3 in the deficient group after treatment and remained stable in the sufficient group. We observed a decreased interferon-γ (IFNγ) secretion by CD4+ T cells in vitamin D deficient group but not in the sufficient group, and a negative correlation between baseline serum vitamin D and IFNγ production. There was no change in the frequency of T helper or regulatory T cell subsets in either group. Increasing serum levels of 25-hydroxyvitamin D are associated with decreased production of IFNγ by CD4+ T cells
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|a Journal Article
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|a Cytometric bead array
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|a Immunophenotyping
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|a Interferon gamma
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|a Relapsing remitting multiple sclerosis
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|a T cells
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|a Vitamin D
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| 650 |
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|a Cytokines
|2 NLM
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|a Vitamins
|2 NLM
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|a Vitamin D
|2 NLM
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| 650 |
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|a 1406-16-2
|2 NLM
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| 650 |
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|a Cholecalciferol
|2 NLM
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| 650 |
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|a 1C6V77QF41
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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|a 82115-62-6
|2 NLM
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| 650 |
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7 |
|a 25-hydroxyvitamin D
|2 NLM
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| 650 |
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7 |
|a A288AR3C9H
|2 NLM
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| 700 |
1 |
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|a El Ayoubi, Nabil K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Esmerian, Maria O
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kazan, Jalal M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Khoury, Samia J
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 181(2017) vom: 13. Aug., Seite 9-15
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:181
|g year:2017
|g day:13
|g month:08
|g pages:9-15
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|u http://dx.doi.org/10.1016/j.clim.2017.05.017
|3 Volltext
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