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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.7b00590
|2 doi
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|a pubmed24n0906.xml
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|a (DE-627)NLM271962240
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|a (NLM)28511536
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Yang, Guang-Ze
|e verfasserin
|4 aut
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|a Biomimetic Silica Nanocapsules for Tunable Sustained Release and Cargo Protection
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 23.01.2019
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|a Date Revised 23.01.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Silica nanocapsules have attracted tremendous interest for encapsulation, protection, and controlled release of various cargoes due to their unique hierarchical core-shell structure. However, it remains challenging to synthesize silica nanocapsules having high cargo-loading capacity and cargo-protection capability without compromising process simplicity and biocompatibility properties. Here, we synthesized oil-core silica-shell nanocapsules under environmentally friendly conditions by a novel emulsion and biomimetic dual-templating approach using a dual-functional protein, in lieu of petrochemical surfactants, thus avoiding the necessities for the removal of toxic components. A light- and pH-sensitive compound can be facilely encapsulated in the silica nanocapsules with the encapsulation efficiency of nearly 100%. Release of the encapsulated active from the nanocapsules was not shown an indication of undesired burst release. Instead, the release can be tuned by controlling the silica-shell thicknesses (i.e., 40 and 77 nm from which the cargo released at 42.0 and 31.3% of the initial amount after 32 days, respectively). The release kinetics were fitted well to the Higuchi model, enabling the possibility of the prediction of release kinetics as a function of shell thickness, thus achieving design-for-purpose silica nanocapsules. Furthermore, the nanocapsules showed excellent alkaline- and sunlight-shielding protective efficacies, which resulted in significantly prolonged half-life of the sensitive cargo. Our biomimetic silica nanocapsules provide a nanocarrier platform for applications that demand process scalability, sustainability, and biocompatibility coupled with unique cargo-protection and controlled-release properties
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Delayed-Action Preparations
|2 NLM
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|a Emulsions
|2 NLM
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|a Nanocapsules
|2 NLM
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|a Silicon Dioxide
|2 NLM
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|a 7631-86-9
|2 NLM
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| 700 |
1 |
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|a Wibowo, David
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yun, Jung-Ho
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Lianzhou
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Middelberg, Anton P J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Chun-Xia
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 33(2017), 23 vom: 13. Juni, Seite 5777-5785
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:33
|g year:2017
|g number:23
|g day:13
|g month:06
|g pages:5777-5785
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|u http://dx.doi.org/10.1021/acs.langmuir.7b00590
|3 Volltext
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