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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.7b00289
|2 doi
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|a pubmed24n0905.xml
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|a (DE-627)NLM271787732
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|a (NLM)28493724
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Kim, Cheol Joo
|e verfasserin
|4 aut
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| 245 |
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|a Tuning the Viscoelasticity of Peptide Vesicles by Adjusting Hydrophobic Helical Blocks Comprising Amphiphilic Polypeptides
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 23.01.2019
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|a Date Revised 23.01.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Amphiphilic block polypeptides of poly(sarcosine)-b-(l-Val-Aib)6 and poly(sarcosine)-b-(l-Leu-Aib)6 and their stereoisomers were self-assembled in water. Three kinds of binary systems of poly(sarcosine)-b-(l-Leu-Aib)6 with poly(sarcosine)-b-poly(d-Leu-Aib)6, poly(sarcosine)-b-poly(l-Val-Aib)6, or poly(sarcosine)-b-(d-Val-Aib)6 generated vesicles of ca. 200 nm diameter. The viscoelasticity of the vesicle membranes was evaluated by the nanoindentation method using AFM in water. The elasticity of the poly(sarcosine)-b-(l-Leu-Aib)6/poly(sarcosine)-b-poly(d-Leu-Aib)6 vesicle was 11-fold higher than that of the egg yolk liposome but decreased in combinations of the Leu- and Val-based amphiphilic polypeptides. The membrane elasticity is found to be adjustable by a suitable combination of helical blocks in terms of stereocomplex formation and the interdigitation of side chains among helices in the molecular assemblies
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Oligopeptides
|2 NLM
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|a Water
|2 NLM
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|a 059QF0KO0R
|2 NLM
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|a Sarcosine
|2 NLM
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|a Z711V88R5F
|2 NLM
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| 700 |
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|a Ueda, Motoki
|e verfasserin
|4 aut
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|a Imai, Tomoya
|e verfasserin
|4 aut
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| 700 |
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|a Sugiyama, Junji
|e verfasserin
|4 aut
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| 700 |
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|a Kimura, Shunsaku
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 33(2017), 22 vom: 06. Juni, Seite 5423-5429
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:33
|g year:2017
|g number:22
|g day:06
|g month:06
|g pages:5423-5429
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|u http://dx.doi.org/10.1021/acs.langmuir.7b00289
|3 Volltext
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