Granzyme B producing B-cells in renal transplant patients

Granzyme B producing B-cells in renal transplant patients

Copyright © 2017 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 184(2017) vom: 10. Nov., Seite 48-53
1. Verfasser: Zhu, Jiqiao (VerfasserIn)
Weitere Verfasser: Zeng, Ye, Dolff, Sebastian, Bienholz, Anja, Lindemann, Monika, Brinkhoff, Alexandra, Schedlowski, Manfred, Xu, Shilei, Sun, Ming, Guberina, Hana, Kirchhof, Julia, Kribben, Andreas, Witzke, Oliver, Wilde, Benjamin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Allograft rejection B-cells Immune tolerance Regulatory B-cells Renal transplantation Adrenal Cortex Hormones Immunosuppressive Agents Interleukins Cyclosporine mehr... 83HN0GTJ6D GZMB protein, human EC 3.4.21.- Granzymes Mycophenolic Acid HU9DX48N0T interleukin-21 MKM3CA6LT1 Tacrolimus WM0HAQ4WNM
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100 1 |a Zhu, Jiqiao  |e verfasserin  |4 aut 
245 1 0 |a Granzyme B producing B-cells in renal transplant patients 
264 1 |c 2017 
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500 |a Date Completed 16.11.2017 
500 |a Date Revised 02.12.2018 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2017 Elsevier Inc. All rights reserved. 
520 |a OBJECTIVES: A separate subset of Granzyme B (GrB) producing B-cells regulating T-cell mediated immunity has been identified. In the present study, we investigated the role of GrB+ B-cells in renal transplant patients (RTX) 
520 |a METHODS: 12 healthy controls (HC) and 26 RTX patients were enrolled. In addition, 19 healthy volunteers treated with cyclosporine A (CsA) were enrolled. GrB+ B-cells were determined via flow cytometry 
520 |a RESULTS: RTX Patients showed a diminished fraction of GrB+ B-cells as compared to HC. CsA treatment of healthy volunteers had no impact on the development of GrB+ B-cells. RTX patients with a history of allograft rejection showed an increased frequency of GrB+ B-cells. RTX patients with at least one episode of CMV viremia tended to have lower GrB+ B-cells as compared to patients without viremic episodes 
520 |a CONCLUSION: We demonstrate that treatment with CsA does not impair the development of GrB+ B-cells. GrB+ B-cells may have a dual role in renal transplantation as regulatory cells to maintain allospecific tolerance and as effector cells enhancing viral control 
650 4 |a Journal Article 
650 4 |a Allograft rejection 
650 4 |a B-cells 
650 4 |a Immune tolerance 
650 4 |a Regulatory B-cells 
650 4 |a Renal transplantation 
650 7 |a Adrenal Cortex Hormones  |2 NLM 
650 7 |a Immunosuppressive Agents  |2 NLM 
650 7 |a Interleukins  |2 NLM 
650 7 |a Cyclosporine  |2 NLM 
650 7 |a 83HN0GTJ6D  |2 NLM 
650 7 |a GZMB protein, human  |2 NLM 
650 7 |a EC 3.4.21.-  |2 NLM 
650 7 |a Granzymes  |2 NLM 
650 7 |a EC 3.4.21.-  |2 NLM 
650 7 |a Mycophenolic Acid  |2 NLM 
650 7 |a HU9DX48N0T  |2 NLM 
650 7 |a interleukin-21  |2 NLM 
650 7 |a MKM3CA6LT1  |2 NLM 
650 7 |a Tacrolimus  |2 NLM 
650 7 |a WM0HAQ4WNM  |2 NLM 
700 1 |a Zeng, Ye  |e verfasserin  |4 aut 
700 1 |a Dolff, Sebastian  |e verfasserin  |4 aut 
700 1 |a Bienholz, Anja  |e verfasserin  |4 aut 
700 1 |a Lindemann, Monika  |e verfasserin  |4 aut 
700 1 |a Brinkhoff, Alexandra  |e verfasserin  |4 aut 
700 1 |a Schedlowski, Manfred  |e verfasserin  |4 aut 
700 1 |a Xu, Shilei  |e verfasserin  |4 aut 
700 1 |a Sun, Ming  |e verfasserin  |4 aut 
700 1 |a Guberina, Hana  |e verfasserin  |4 aut 
700 1 |a Kirchhof, Julia  |e verfasserin  |4 aut 
700 1 |a Kribben, Andreas  |e verfasserin  |4 aut 
700 1 |a Witzke, Oliver  |e verfasserin  |4 aut 
700 1 |a Wilde, Benjamin  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Clinical immunology (Orlando, Fla.)  |d 1999  |g 184(2017) vom: 10. Nov., Seite 48-53  |w (DE-627)NLM098196855  |x 1521-7035  |7 nnns 
773 1 8 |g volume:184  |g year:2017  |g day:10  |g month:11  |g pages:48-53 
856 4 0 |u http://dx.doi.org/10.1016/j.clim.2017.04.016  |3 Volltext 
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