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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.04.008
|2 doi
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|a pubmed24n0904.xml
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|a (DE-627)NLM271425768
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|a (NLM)28456719
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|a (PII)S1521-6616(17)30278-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Jansen, M A E
|e verfasserin
|4 aut
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|a Abnormalities in CD57+ cytotoxic T cells and Vδ1+ γδT cells in subclinical celiac disease in childhood are affected by cytomegalovirus. The Generation R Study
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 13.12.2017
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|a Date Revised 06.02.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a Celiac disease (CD) is a digestive and autoimmune disorder driven by an immune response to modified gluten peptides. Affected intestines show infiltrates of various T-cell and NK-cell subsets. It is currently unclear if individuals with subclinical CD have systemic abnormalities in immune cells. We here studied whether subclinical CD is associated with changes in blood CD57-expressing and Vδ1-expressing lymphocytes in children, and whether cytomegalovirus (CMV) infection modifies this association. Included were 1068 children from the Generation R Study. Serum Immunoglobulin G (IgG) levels against CMV were measured by ELISA; Tissue transglutaminase type 2 antibody (TG2A) levels with fluorescence enzyme immunoassay (FEIA). Duodenal biopsies, additional Human Leukocyte Antigen (HLA) DQ 2.2, 2.5 and 8 and endomysial antibody (EMA) typing were performed in TG2A positive children. Subclinical CD cases (n=12) had 1.8 fold (95% CI 1.06; 3.1) fewer Vδ1+ T cells which was predominantly observed in CMV seronegative children (p-interaction 0.02), and 2.7 fold (95% CI 1.25; 5.99) more CD57+ T cells than HLA DQ2/-DQ8 positive controls (n=339). Hence, children with subclinical CD have alterations in specific blood T cell subsets that are linked to viral pathology. The observed interaction effect between subclinical CD and CMV may contribute to the understanding of disease pathogenesis
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a CD57+ T cells
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| 650 |
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|a Celiac disease
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| 650 |
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|a Child
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|a Cohort study
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|a TG2A levels
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| 650 |
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|a Vδ1+ T cells
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| 650 |
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|a CD57 Antigens
|2 NLM
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| 650 |
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|a Receptors, Antigen, T-Cell, gamma-delta
|2 NLM
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| 700 |
1 |
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|a van den Heuvel, D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jaddoe, V W V
|e verfasserin
|4 aut
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| 700 |
1 |
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|a van Zelm, M C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Moll, H A
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 183(2017) vom: 23. Okt., Seite 233-239
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:183
|g year:2017
|g day:23
|g month:10
|g pages:233-239
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2017.04.008
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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|a GBV_ILN_350
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|a AR
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|d 183
|j 2017
|b 23
|c 10
|h 233-239
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