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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.03.016
|2 doi
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|a pubmed24n0902.xml
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|a (DE-627)NLM270785795
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|a (NLM)28390966
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|a (PII)S1521-6616(16)30294-7
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Chowdhury, Abhra Chandra
|e verfasserin
|4 aut
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| 245 |
1 |
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|a IL-17 and IFN-γ producing NK and γδ-T cells are preferentially expanded in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthritis
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 13.12.2017
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|a Date Revised 04.12.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a The IL-17/1L-23 axis is important in the pathogenesis of spondyloarthropathy. Innate cells produce IL-17 in addition to Th17 cells. We studied the frequencies of natural killer (NK) (total, CD56bright, CD56dim, perforin+ and granzyme+), NK-T, γδ-T, and IFN-γ+, IL-17+ NK and γδ-T cells in peripheral blood (PB) and synovial fluid (SF) of ReA/uSpA patients. PB from 45 patients and paired SF from 39 patients were studied, together with PB from 18 healthy controls (HC). The frequency of γδ-T cells was decreased (p<0.05) while IL-17 producing NK and γδ-T cells were increased (p<0.05) in PB of patients as compared to HC. In SF, CD56bright NK cells were increased (p<0.001) but had reduced expression of perforin and granzyme (p<0.0001) as compared to PB. Frequency of IL-17+, IFN-γ+ NK and γδ-T cells was higher in SF as compared to PB (p<0.05). We suggest that innate cells by producing pro-inflammatory cytokines may contribute to pathogenesis
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| 650 |
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|a Journal Article
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|a Gamma Delta T cells
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|a Inflammation
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|a Interleukin 17
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| 650 |
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4 |
|a Natural killer cells
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| 650 |
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|a Synovial fluid
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|a Interleukin-17
|2 NLM
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| 650 |
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|a PHB2 protein, human
|2 NLM
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| 650 |
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|a Prohibitins
|2 NLM
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| 650 |
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|a Receptors, Antigen, T-Cell, gamma-delta
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Chaurasia, Smriti
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mishra, Shravan Kumar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Aggarwal, Amita
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Misra, Ramnath
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 183(2017) vom: 01. Okt., Seite 207-212
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:183
|g year:2017
|g day:01
|g month:10
|g pages:207-212
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2017.03.016
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 183
|j 2017
|b 01
|c 10
|h 207-212
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