Quantitative Particle-Cell Interaction : Some Basic Physicochemical Pitfalls
There are numerous reports about particle-cell interaction studies in the literature. Many of those are performed in two-dimensional cell cultures. While the interpretation of such studies seems trivial at first sight, in fact for quantitative analysis some basic physical and physicochemical bases n...
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1992. - 33(2017), 27 vom: 11. Juli, Seite 6639-6646 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2017
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't |
| Zusammenfassung: | There are numerous reports about particle-cell interaction studies in the literature. Many of those are performed in two-dimensional cell cultures. While the interpretation of such studies seems trivial at first sight, in fact for quantitative analysis some basic physical and physicochemical bases need to be considered. This starts with the dispersion of the particles, for which gravity, Brownian motion, and interparticle interactions need to be considered. The respective strength of these interactions determines whether the particles will sediment, are dispersed, or are agglomerated. This in turn largely influences their interaction with cells. While in the case of well-dispersed particles only a fraction of them will come into contact with cells in a two-dimensional culture, (agglomeration-induced) sedimentation drives the particles toward the cell surface, resulting in enhanced uptake |
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| Beschreibung: | Date Completed 22.01.2019 Date Revised 05.04.2024 published: Print-Electronic ErratumIn: Langmuir. 2024 Apr 5;:. - PMID 38578077 Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/acs.langmuir.6b04629 |