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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erx059
|2 doi
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|a pubmed24n0901.xml
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|a (DE-627)NLM270578501
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|a (NLM)28369642
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Biala, Wanda
|e verfasserin
|4 aut
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|a Medicago truncatula ABCG10 is a transporter of 4-coumarate and liquiritigenin in the medicarpin biosynthetic pathway
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 22.02.2018
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|a Date Revised 04.12.2021
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental Biology.
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|a The ABCG10 protein of the model legume Medicago truncatula is required for efficient de novo production of the phenylpropanoid-derived phytoalexin medicarpin. Silencing the expression of MtABCG10 results, inter alia, in a lower accumulation of medicarpin and its precursors. In this study, we demonstrate that the impairment of medicarpin biosynthesis can be partially averted by the exogenous application of 4-coumarate, an early precursor of the core phenylpropanoid pathway, and the deoxyisoflavonoid formononetin. Experiments conducted using HPLC/MS in a heterologous system as well as in vitro transport assays with labelled substrate revealed that MtABCG10 is responsible for the membrane translocation of 4-coumarate and liquiritigenin, molecules representing key branching points in the phenylpropanoid pathway. The identification of transporters participating in the distribution of precursors is an important step in understanding phenylpropanoid biosynthesis
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|a Journal Article
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|a 4-coumarate
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|a ABC transporters
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|a Medicago truncatula
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|a biotic stress
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|a liquiritigenin
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|a medicarpin
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|a phenylpropanoid pathway
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|a ATP Binding Cassette Transporter, Subfamily G
|2 NLM
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|a Coumaric Acids
|2 NLM
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|a Flavanones
|2 NLM
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|a Plant Proteins
|2 NLM
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|a Propionates
|2 NLM
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|a Pterocarpans
|2 NLM
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|a medicarpin
|2 NLM
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| 650 |
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|a 6TX086I6IG
|2 NLM
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| 650 |
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|a p-coumaric acid
|2 NLM
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| 650 |
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|a IBS9D1EU3J
|2 NLM
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| 650 |
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|a liquiritigenin
|2 NLM
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| 650 |
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|a T194LKP9W6
|2 NLM
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| 700 |
1 |
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|a Banasiak, Joanna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jarzyniak, Karolina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pawela, Aleksandra
|e verfasserin
|4 aut
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| 700 |
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|a Jasinski, Michal
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 68(2017), 12 vom: 01. Juni, Seite 3231-3241
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
1 |
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|g volume:68
|g year:2017
|g number:12
|g day:01
|g month:06
|g pages:3231-3241
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|u http://dx.doi.org/10.1093/jxb/erx059
|3 Volltext
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|d 68
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