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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2017.03.001
|2 doi
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|a eng
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| 100 |
1 |
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|a Mirza, Ali
|e verfasserin
|4 aut
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1 |
4 |
|a The gut microbiome and microbial translocation in multiple sclerosis
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|c 2017
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 13.12.2017
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|a Date Revised 15.02.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2017 Elsevier Inc. All rights reserved.
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|a Individuals with multiple sclerosis (MS) have a distinct intestinal microbial community (microbiota) and increased low-grade translocation of bacteria from the intestines into the circulation. The observed change of intestinal bacteria in MS patients regulate immune functions involved in MS pathogenesis. These functions include: systemic and central nervous system (CNS) immunity (including peripheral regulatory T cell function), the blood-brain barrier (BBB) permeability and CNS-resident cell activity. This review discusses the MS intestinal microbiota implication on MS systemic- and CNS-immunopathology. We introduce the possible contributions of MS low-grade microbial translocation (LG-MT) to the development of MS, and end on a discussion on microbiota therapies for MS patients
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|a Journal Article
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|a Review
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a CNS
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| 650 |
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4 |
|a Gut-brain axis
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| 650 |
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4 |
|a Intestinal permeability
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| 650 |
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4 |
|a Microbial translocation
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| 650 |
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4 |
|a Microbiome
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| 650 |
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4 |
|a Multiple sclerosis
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| 700 |
1 |
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|a Mao-Draayer, Yang
|e verfasserin
|4 aut
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
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|g 183(2017) vom: 18. Okt., Seite 213-224
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|g volume:183
|g year:2017
|g day:18
|g month:10
|g pages:213-224
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|u http://dx.doi.org/10.1016/j.clim.2017.03.001
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