Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis Toward Therapy for Glaucoma

Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis : Toward Therapy for Glaucoma

© 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 29(2017), 16 vom: 27. Apr.
1. Verfasser: Chandrawati, Rona (VerfasserIn)
Weitere Verfasser: Chang, Jason Y H, Reina-Torres, Ester, Jumeaux, Coline, Sherwood, Joseph M, Stamer, W Daniel, Zelikin, Alexander N, Overby, Darryl R, Stevens, Molly M
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article glaucoma layer-by-layer capsules liposomes nitric oxide β-galactosidase Nitric Oxide 31C4KY9ESH
Beschreibung
Zusammenfassung:© 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. A NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model
Beschreibung:Date Completed 15.01.2019
Date Revised 12.11.2023
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201604932