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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1155/2017/2875904
|2 doi
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|a eng
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| 100 |
1 |
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|a Yao, Lulu
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Enhancing NMDA Receptor Function
|b Recent Progress on Allosteric Modulators
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 20.09.2017
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The N-methyl-D-aspartate receptors (NMDARs) are subtype glutamate receptors that play important roles in excitatory neurotransmission and synaptic plasticity. Their hypo- or hyperactivation are proposed to contribute to the genesis or progression of various brain diseases, including stroke, schizophrenia, depression, and Alzheimer's disease. Past efforts in targeting NMDARs for therapeutic intervention have largely been on inhibitors of NMDARs. In light of the discovery of NMDAR hypofunction in psychiatric disorders and perhaps Alzheimer's disease, efforts in boosting NMDAR activity/functions have surged in recent years. In this review, we will focus on enhancing NMDAR functions, especially on the recent progress in the generation of subunit-selective, allosteric positive modulators (PAMs) of NMDARs. We shall also discuss the usefulness of these newly developed NMDAR-PAMs
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|a Journal Article
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|a Review
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|a Research Support, Non-U.S. Gov't
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|a Excitatory Amino Acid Agonists
|2 NLM
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| 650 |
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|a Excitatory Amino Acid Antagonists
|2 NLM
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| 650 |
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|a Receptors, N-Methyl-D-Aspartate
|2 NLM
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| 700 |
1 |
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|a Zhou, Qiang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2017(2017) vom: 16., Seite 2875904
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|x 1687-5443
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|g volume:2017
|g year:2017
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|g pages:2875904
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|u http://dx.doi.org/10.1155/2017/2875904
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