Positive selection of type II collagen-reactive CD80high marginal zone B cells in DBA/1 mice

Positive selection of type II collagen-reactive CD80high marginal zone B cells in DBA/1 mice

Copyright © 2017 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 178(2017) vom: 28. Mai, Seite 64-73
1. Verfasser: Park, Chanho (VerfasserIn)
Weitere Verfasser: Kho, In Seong, In Yang, Jeong, Kim, Min-Jung, Park, Sunhoo, Cha, Hoon-Suk, Lee, Jaejoon, Kim, Tae Jin
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Autoimmunity Autoreactive B cell CD80 Collagen-induced arthritis DBA/1 mouse Marginal zone B cell B7-1 Antigen Collagen Type II Ly9 protein, mouse mehr... Piperidines Protein Kinase Inhibitors Pyrazoles Pyrimidines Signaling Lymphocytic Activation Molecule Family Slamf6 protein, mouse Tnfrsf13b protein, mouse Transmembrane Activator and CAML Interactor Protein ibrutinib 1X70OSD4VX Protein-Tyrosine Kinases EC 2.7.10.1 Agammaglobulinaemia Tyrosine Kinase EC 2.7.10.2 Btk protein, mouse Adenine JAC85A2161
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100 1 |a Park, Chanho  |e verfasserin  |4 aut 
245 1 0 |a Positive selection of type II collagen-reactive CD80high marginal zone B cells in DBA/1 mice 
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520 |a To investigate whether dysregulated selection of autoreactive marginal zone (MZ) B cells is involved in autoimmune diseases, we examined MZ B cell profile in multiple strains of mice, and found that type II collagen (CII)-reactive autoreactive CD80high MZ B cells spontaneously developed in the DBA/1, but not in C57BL/6 mice. CD80high MZ B cells that were characteristically found in DBA/1 mice expressed higher levels of TACI, SLAM3, and SLAM6 than the usual CD80low MZ B cells. Notably, the CD80high MZ B cells were more sensitive to ibrutinib, a Bruton's tyrosine kinase inhibitor, than CD80low MZ or follicular B cells and their transient depletion via intravenous injection of ibrutinib significantly delayed the induction of collagen-induced arthritis (CIA). In summary, we suggest that the positive selection of CII-reactive CD80high MZ B cells is a critical homeostatic process predisposing the DBA/1 mice to the CIA induction 
650 4 |a Journal Article 
650 4 |a Autoimmunity 
650 4 |a Autoreactive B cell 
650 4 |a CD80 
650 4 |a Collagen-induced arthritis 
650 4 |a DBA/1 mouse 
650 4 |a Marginal zone B cell 
650 7 |a B7-1 Antigen  |2 NLM 
650 7 |a Collagen Type II  |2 NLM 
650 7 |a Ly9 protein, mouse  |2 NLM 
650 7 |a Piperidines  |2 NLM 
650 7 |a Protein Kinase Inhibitors  |2 NLM 
650 7 |a Pyrazoles  |2 NLM 
650 7 |a Pyrimidines  |2 NLM 
650 7 |a Signaling Lymphocytic Activation Molecule Family  |2 NLM 
650 7 |a Slamf6 protein, mouse  |2 NLM 
650 7 |a Tnfrsf13b protein, mouse  |2 NLM 
650 7 |a Transmembrane Activator and CAML Interactor Protein  |2 NLM 
650 7 |a ibrutinib  |2 NLM 
650 7 |a 1X70OSD4VX  |2 NLM 
650 7 |a Protein-Tyrosine Kinases  |2 NLM 
650 7 |a EC 2.7.10.1  |2 NLM 
650 7 |a Agammaglobulinaemia Tyrosine Kinase  |2 NLM 
650 7 |a EC 2.7.10.2  |2 NLM 
650 7 |a Btk protein, mouse  |2 NLM 
650 7 |a EC 2.7.10.2  |2 NLM 
650 7 |a Adenine  |2 NLM 
650 7 |a JAC85A2161  |2 NLM 
700 1 |a Kho, In Seong  |e verfasserin  |4 aut 
700 1 |a In Yang, Jeong  |e verfasserin  |4 aut 
700 1 |a Kim, Min-Jung  |e verfasserin  |4 aut 
700 1 |a Park, Sunhoo  |e verfasserin  |4 aut 
700 1 |a Cha, Hoon-Suk  |e verfasserin  |4 aut 
700 1 |a Lee, Jaejoon  |e verfasserin  |4 aut 
700 1 |a Kim, Tae Jin  |e verfasserin  |4 aut 
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856 4 0 |u http://dx.doi.org/10.1016/j.clim.2017.01.015  |3 Volltext 
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