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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1155/2016/4545826
|2 doi
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|a pubmed24n0893.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hang, Jianfeng
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 29.08.2017
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|a Date Revised 02.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Prestin is the motor protein expressed in the cochlear outer hair cells (OHCs) of mammalian inner ear. The electromotility of OHCs driven by prestin is responsible for the cochlear amplification which is required for normal hearing in adult animals. Postnatal expression of prestin and activity of OHCs may contribute to the maturation of hearing in rodents. However, the temporal and spatial expression of prestin in cochlea during the development is not well characterized. In the present study, we examined the expression and function of prestin from the OHCs in apical, middle, and basal turns of the cochleae of postnatal rats. Prestin first appeared at postnatal day 6 (P6) for basal turn, P7 in middle turn, and P9 for apical turn of cochlea. The expression level increased progressively over the next few days and by P14 reached the mature level for all three segments. By comparison with the time course of the development of auditory brainstem response for different frequencies, our data reveal that prestin expression synchronized with the hearing development. The present study suggests that the onset time of hearing may require the expression of prestin and is determined by the mature function of OHCs
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|a Journal Article
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|a Anion Transport Proteins
|2 NLM
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| 650 |
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|a Slc26a5 protein, rat
|2 NLM
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| 650 |
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7 |
|a Sulfate Transporters
|2 NLM
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| 700 |
1 |
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|a Pan, Wenlu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Aoshuang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Shun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Cuixian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fu, Mingyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Jie
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2016(2016) vom: 18., Seite 4545826
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnns
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| 773 |
1 |
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|g volume:2016
|g year:2016
|g day:18
|g pages:4545826
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|u http://dx.doi.org/10.1155/2016/4545826
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