Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory

Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory

Neural plasticity is associated with memory formation. The coordinated refinement and interaction between cortical glutamatergic and GABAergic neurons remain elusive in associative memory, which we examine in a mouse model of associative learning. In the mice that show odorant-induced whisker motion...

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Veröffentlicht in:Neural plasticity. - 1998. - 2016(2016) vom: 28., Seite 5648390
1. Verfasser: Yan, Fenxia (VerfasserIn)
Weitere Verfasser: Gao, Zilong, Chen, Pin, Huang, Li, Wang, Dangui, Chen, Na, Wu, Ruixiang, Feng, Jing, Cui, Shan, Lu, Wei, Wang, Jin-Hui
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Neural plasticity
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Glutamic Acid 3KX376GY7L
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520 |a Neural plasticity is associated with memory formation. The coordinated refinement and interaction between cortical glutamatergic and GABAergic neurons remain elusive in associative memory, which we examine in a mouse model of associative learning. In the mice that show odorant-induced whisker motion after pairing whisker and odor stimulations, the barrel cortical glutamatergic and GABAergic neurons are recruited to encode the newly learnt odor signal alongside the innate whisker signal. These glutamatergic neurons are functionally upregulated, and GABAergic neurons are refined in a homeostatic manner. The mutual innervations between these glutamatergic and GABAergic neurons are upregulated. The analyses by high throughput sequencing show that certain microRNAs related to regulating synapses and neurons are involved in this cross-modal reflex. Thus, the coactivation of the sensory cortices through epigenetic processes recruits their glutamatergic and GABAergic neurons to be the associative memory cells as well as drive their coordinated refinements toward the optimal state for the storage of the associated signals 
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700 1 |a Gao, Zilong  |e verfasserin  |4 aut 
700 1 |a Chen, Pin  |e verfasserin  |4 aut 
700 1 |a Huang, Li  |e verfasserin  |4 aut 
700 1 |a Wang, Dangui  |e verfasserin  |4 aut 
700 1 |a Chen, Na  |e verfasserin  |4 aut 
700 1 |a Wu, Ruixiang  |e verfasserin  |4 aut 
700 1 |a Feng, Jing  |e verfasserin  |4 aut 
700 1 |a Cui, Shan  |e verfasserin  |4 aut 
700 1 |a Lu, Wei  |e verfasserin  |4 aut 
700 1 |a Wang, Jin-Hui  |e verfasserin  |4 aut 
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