Reversible Vesicle-to-Disk Transitions of Liposomes Induced by the Self-Assembly of Water-Soluble Porphyrins

Structural control of lipid membranes is important for mechanisms underlying biological functions and for creating high-functionality soft materials. We demonstrate the reversible control of vesicle structures (liposomes) using supramolecular assemblies. Specifically, water-soluble anionic porphyrin...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 33(2017), 4 vom: 31. Jan., Seite 1023-1029
1. Verfasser: Sugikawa, Kouta (VerfasserIn)
Weitere Verfasser: Takamatsu, Yutaro, Yasuhara, Kazuma, Ueda, Masafumi, Ikeda, Atsushi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Liposomes Porphyrins Water 059QF0KO0R
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520 |a Structural control of lipid membranes is important for mechanisms underlying biological functions and for creating high-functionality soft materials. We demonstrate the reversible control of vesicle structures (liposomes) using supramolecular assemblies. Specifically, water-soluble anionic porphyrin molecules interact with positively charged lipid membrane surfaces to form one-dimensional self-assembled structures (J-aggregates) under acidic conditions. Cryogenic transmission electron microscopy revealed that porphyrin J-aggregates on the membrane surface induced an extensive structural change from vesicles to layered disks. Neutralization of the solution deformed the porphyrin J-aggregates, thereby reforming nanosized liposomes from the layered disks 
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700 1 |a Yasuhara, Kazuma  |e verfasserin  |4 aut 
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700 1 |a Ikeda, Atsushi  |e verfasserin  |4 aut 
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