Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus

Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus

Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 176(2017) vom: 07. März, Seite 12-22
1. Verfasser: Young, Nicholas A (VerfasserIn)
Weitere Verfasser: Valiente, Giancarlo R, Hampton, Jeffrey M, Wu, Lai-Chu, Burd, Craig J, Willis, William L, Bruss, Michael, Steigelman, Holly, Gotsatsenko, Maya, Amici, Stephanie A, Severin, Mary, Claverie, Lucila Marino, Guerau-de-Arellano, Mireia, Lovett-Racke, Amy, Ardoin, Stacy, Jarjour, Wael N
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2017
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Estrogen Extracellular vesicles Innate immunity Systemic lupus erythematosus Toll-like receptor (TLR)8 microRNA (miR) Chemokines mehr... Estrogens Ligands MIRN21 microRNA, human MicroRNAs STAT1 Transcription Factor STAT1 protein, human TLR8 protein, human Toll-Like Receptor 8
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100 1 |a Young, Nicholas A  |e verfasserin  |4 aut 
245 1 0 |a Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus 
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500 |a Date Revised 04.04.2020 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved. 
520 |a Recent studies implicate innate immunity to systemic lupus erythematosus (SLE) pathogenesis. Toll-like receptor (TLR)8 is estrogen-regulated and binds viral ssRNA to stimulate innate immune responses, but recent work indicates that microRNA (miR)-21 within extracellular vesicles (EVs) can also trigger this receptor. Our objective was to examine TLR8 expression/activation to better understand sex-biased responses involving TLR8 in SLE. Our data identify an estrogen response element that promotes STAT1 expression and demonstrate STAT1-dependent transcriptional activation of TLR8 with estrogen stimulation. In lieu of viral ssRNA activation, we explored EV-encapsulated miR-21 as an endogenous ligand and observed induction of both TLR8 and cytokine expression in vitro. Moreover, extracellular miR detection was found predominantly within EVs. Thus, just as a cytokine or chemokine, EV-encapsulated miR-21 can act as an inflammatory signaling molecule, or miRokine, by virtue of being an endogenous ligand of TLR8. Collectively, our data elucidates a novel innate inflammatory pathway in SLE 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Estrogen 
650 4 |a Extracellular vesicles 
650 4 |a Innate immunity 
650 4 |a Systemic lupus erythematosus 
650 4 |a Toll-like receptor (TLR)8 
650 4 |a microRNA (miR) 
650 7 |a Chemokines  |2 NLM 
650 7 |a Estrogens  |2 NLM 
650 7 |a Ligands  |2 NLM 
650 7 |a MIRN21 microRNA, human  |2 NLM 
650 7 |a MicroRNAs  |2 NLM 
650 7 |a STAT1 Transcription Factor  |2 NLM 
650 7 |a STAT1 protein, human  |2 NLM 
650 7 |a TLR8 protein, human  |2 NLM 
650 7 |a Toll-Like Receptor 8  |2 NLM 
700 1 |a Valiente, Giancarlo R  |e verfasserin  |4 aut 
700 1 |a Hampton, Jeffrey M  |e verfasserin  |4 aut 
700 1 |a Wu, Lai-Chu  |e verfasserin  |4 aut 
700 1 |a Burd, Craig J  |e verfasserin  |4 aut 
700 1 |a Willis, William L  |e verfasserin  |4 aut 
700 1 |a Bruss, Michael  |e verfasserin  |4 aut 
700 1 |a Steigelman, Holly  |e verfasserin  |4 aut 
700 1 |a Gotsatsenko, Maya  |e verfasserin  |4 aut 
700 1 |a Amici, Stephanie A  |e verfasserin  |4 aut 
700 1 |a Severin, Mary  |e verfasserin  |4 aut 
700 1 |a Claverie, Lucila Marino  |e verfasserin  |4 aut 
700 1 |a Guerau-de-Arellano, Mireia  |e verfasserin  |4 aut 
700 1 |a Lovett-Racke, Amy  |e verfasserin  |4 aut 
700 1 |a Ardoin, Stacy  |e verfasserin  |4 aut 
700 1 |a Jarjour, Wael N  |e verfasserin  |4 aut 
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