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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erw446
|2 doi
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|a pubmed24n0891.xml
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|a (DE-627)NLM267488335
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|a (NLM)28025315
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Gimeno-Ferrer, Fátima
|e verfasserin
|4 aut
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|a α2-COP is involved in early secretory traffic in Arabidopsis and is required for plant growth
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 17.11.2017
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|a Date Revised 09.01.2021
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology.
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|a COP (coat protein) I-coated vesicles mediate intra-Golgi transport and retrograde transport from the Golgi to the endoplasmic reticulum. These vesicles form through the action of the small GTPase ADP-ribosylation factor 1 (ARF1) and the COPI heptameric protein complex (coatomer), which consists of seven subunits (α-, β-, β'-, γ-, δ-, ε- and ζ-COP). In contrast to mammals and yeast, several isoforms for coatomer subunits, with the exception of γ and δ, have been identified in Arabidopsis. To understand the role of COPI proteins in plant biology, we have identified and characterized a loss-of-function mutant of α2-COP, an Arabidopsis α-COP isoform. The α2-cop mutant displayed defects in plant growth, including small rosettes, stems and roots and mislocalization of p24δ5, a protein of the p24 family containing a C-terminal dilysine motif involved in COPI binding. The α2-cop mutant also exhibited abnormal morphology of the Golgi apparatus. Global expression analysis of the α2-cop mutant revealed altered expression of plant cell wall-associated genes. In addition, a strong upregulation of SEC31A, which encodes a subunit of the COPII coat, was observed in the α2-cop mutant; this also occurs in a mutant of a gene upstream of COPI assembly, GNL1, which encodes an ARF-guanine nucleotide exchange factor (GEF). These findings suggest that loss of α2-COP affects the expression of secretory pathway genes
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|a Journal Article
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|a Arabidopsis
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|a COPI
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|a COPII
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|a Golgi apparatus
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|a coat protein
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|a p24 family protein
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|a α1-COP
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|a α2-COP
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|a SEC31
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|a Arabidopsis Proteins
|2 NLM
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|a Coatomer Protein
|2 NLM
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| 650 |
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|a AT2G32950 protein, Arabidopsis
|2 NLM
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| 650 |
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|a EC 2.3.2.27
|2 NLM
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| 650 |
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|a Ubiquitin-Protein Ligases
|2 NLM
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| 650 |
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|a EC 2.3.2.27
|2 NLM
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| 700 |
1 |
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|a Pastor-Cantizano, Noelia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bernat-Silvestre, César
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Selvi-Martínez, Pilar
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vera-Sirera, Francisco
|e verfasserin
|4 aut
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|a Gao, Caiji
|e verfasserin
|4 aut
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|a Perez-Amador, Miguel Angel
|e verfasserin
|4 aut
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| 700 |
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|a Jiang, Liwen
|e verfasserin
|4 aut
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| 700 |
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|a Aniento, Fernando
|e verfasserin
|4 aut
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|a Marcote, María Jesús
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 68(2017), 3 vom: 01. Jan., Seite 391-401
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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| 773 |
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|g volume:68
|g year:2017
|g number:3
|g day:01
|g month:01
|g pages:391-401
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|u http://dx.doi.org/10.1093/jxb/erw446
|3 Volltext
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|d 68
|j 2017
|e 3
|b 01
|c 01
|h 391-401
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