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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.12.001
|2 doi
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|a eng
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| 100 |
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|a Zhou, Juan
|e verfasserin
|4 aut
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| 245 |
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|a CD3+CD56+ natural killer T cell activity in children with different forms of juvenile idiopathic arthritis and the influence of etanercept treatment on polyarticular subgroup
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|c 2017
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 05.06.2017
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|a Date Revised 06.02.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016. Published by Elsevier Inc.
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|a Juvenile idiopathic arthritis (JIA) has three major onset types with widely varying clinical features. We assessed the natural killer T (NKT) cell function in patients with different JIA subtypes, and found systemic patients exhibited lower NKT cell counts, perforin and granzyme B expression, while the pauciarticular and polyarticular patients displayed higher perforin and granzyme B expression as compared with the controls. The synovial fluid had more NKT cells with higher levels of perforin, granzyme B, and tumour necrosis factor (TNF)-α than peripheral cells. The polyarticular patients that responded to etanercept had lower NKT cell counts, intracellular perforin, granzyme B and the mean fluorescence intensity of TNF-α than the patients that did not respond. Treatment with etanercept reduced the granzyme B and perforin, interferon (IFN)-γ and TNF-α expression in NKT cells in the responsive group. Therefore, a higher NKT cell function may indicate a decreased response to etanercept in polyarticular patients
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Etanercept
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| 650 |
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|a Juvenile idiopathic arthritis
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|a Natural killer T cell
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|a CD3 Complex
|2 NLM
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|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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|a Perforin
|2 NLM
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| 650 |
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|a 126465-35-8
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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|a 82115-62-6
|2 NLM
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| 650 |
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|a Granzymes
|2 NLM
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| 650 |
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|a EC 3.4.21.-
|2 NLM
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| 650 |
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|a Etanercept
|2 NLM
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| 650 |
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|a OP401G7OJC
|2 NLM
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| 700 |
1 |
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|a Ding, Yuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Feng, Ye
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Xuemei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Xiaodong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 176(2017) vom: 01. März, Seite 1-11
|w (DE-627)NLM098196855
|x 1521-7035
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|g volume:176
|g year:2017
|g day:01
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|g pages:1-11
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|u http://dx.doi.org/10.1016/j.clim.2016.12.001
|3 Volltext
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