Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk

Reduced γ-Aminobutyric Acid and Glutamate+Glutamine Levels in Drug-Naïve Patients with First-Episode Schizophrenia but Not in Those at Ultrahigh Risk

Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia. However, it remains unclear how these abnormalities impact the onset and course of psychosis. In the present...

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Veröffentlicht in:Neural plasticity. - 1998. - 2016(2016) vom: 07., Seite 3915703
1. Verfasser: Wang, Junjie (VerfasserIn)
Weitere Verfasser: Tang, Yingying, Zhang, Tianhong, Cui, Huiru, Xu, Lihua, Zeng, Botao, Li, Yu, Li, Gaiying, Li, Chunbo, Liu, Hui, Lu, Zheng, Zhang, Jianye, Wang, Jijun
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Neural plasticity
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Glutamine 0RH81L854J Glutamic Acid 3KX376GY7L gamma-Aminobutyric Acid 56-12-2
Beschreibung
Zusammenfassung:Altered γ-aminobutyric acid (GABA), glutamate (Glu) levels, and an imbalance between GABAergic and glutamatergic neurotransmissions have been involved in the pathophysiology of schizophrenia. However, it remains unclear how these abnormalities impact the onset and course of psychosis. In the present study, 21 drug-naïve subjects at ultrahigh risk for psychosis (UHR), 16 drug-naïve patients with first-episode schizophrenia (FES), and 23 healthy controls (HC) were enrolled. In vivo GABA and glutamate+glutamine (Glx) levels in the medial prefrontal cortex were measured using proton magnetic resonance spectroscopy. Medial prefrontal GABA and Glx levels in FES patients were significantly lower than those in HC and UHR, respectively. GABA and Glx levels in UHR were comparable with those in HC. In each group, there was a positive correlation between GABA and Glx levels. Reduced medial prefrontal GABA and Glx levels thus may play an important role in the early stages of schizophrenia
Beschreibung:Date Completed 26.10.2017
Date Revised 13.11.2018
published: Print-Electronic
Citation Status MEDLINE
ISSN:1687-5443
DOI:10.1155/2016/3915703