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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.4548
|2 doi
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|a eng
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|a Jézéquel, Tangi
|e verfasserin
|4 aut
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|a The new face of isotopic NMR at natural abundance
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 05.03.2018
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|a Date Revised 05.03.2018
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Copyright © 2016 John Wiley & Sons, Ltd.
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|a The most widely used method for isotope analysis at natural abundance is isotope ratio monitoring by Mass Spectrometry (irm-MS) which provides bulk isotopic composition in 2 H, 13 C, 15 N, 18 O or 34 S. However, in the 1980s, the direct access to Site-specific Natural Isotope Fractionation by Nuclear Magnetic Resonance (SNIF-NMRTM ) was immediately recognized as a powerful technique to authenticate the origin of natural or synthetic products. The initial - and still most popular - application consisted in detecting the chaptalization of wines by irm-2 H NMR. The approach has been extended to a wide range of methodologies over the last decade, paving the way to a wide range of applications, not only in the field of authentication but also to study metabolism. In particular, the emerging irm-13 C NMR approach delivers direct access to position-specific 13 C isotope content at natural abundance. After highlighting the application scope of irm-NMR (2 H and 13 C), this article describes the major improvements which made possible to reach the required accuracy of 1‰ (0.1%) in irm-13 C NMR. The last part of the manuscript summarizes the different steps to perform isotope analysis as a function of the sample properties (concentration, peak overlap) and the kind of targeted isotopic information (authentication, affiliation). Copyright © 2016 John Wiley & Sons, Ltd
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|a Journal Article
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|a Position-Specific Isotope Analysis
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|a SNIF-NMR
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|a internal standard
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|a irm-NMR
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|a isotope analysis
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|a Joubert, Valentin
|e verfasserin
|4 aut
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|a Giraudeau, Patrick
|e verfasserin
|4 aut
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|a Remaud, Gérald S
|e verfasserin
|4 aut
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| 700 |
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|a Akoka, Serge
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 55(2017), 2 vom: 15. Feb., Seite 77-90
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|g year:2017
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