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20231224215411.0 |
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cr uuu---uuuuu |
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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.11.014
|2 doi
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|a pubmed24n0889.xml
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|a (DE-627)NLM266840248
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|a (NLM)27919819
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|a (PII)S1521-6616(16)30435-1
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Taraldsrud, Eli
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency
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|c 2017
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 05.06.2017
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|a Date Revised 06.02.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016 Elsevier Inc. All rights reserved.
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|a Patients with common variable immunodeficiency (CVID) constitute a clinically and immunologically heterogeneous group characterized by B-cell dysfunction with hypogammaglobulinemia and defective immunoglobulin class switch of unknown etiology. Current classification systems are insufficient to achieve precise disease management. Characterization of signaling pathways essential for B-cell differentiation and class switch could provide new means to stratify patients. We evaluated constitutive and induced signaling by phospho-specific flow cytometry in 26 CVID patients and 18 healthy blood donors. Strong responses were induced both in CVID and healthy donor B cells upon activation. In contrast, constitutive phosphorylation levels of STAT3,-5,-6, Erk, PLC-γ and Syk were significantly increased in CVID B cells only. Hierarchical clustering revealed a subgroup of CVID patients with elevated constitutive phosphorylation of Syk and PLC-γ. All these patients had non-infectious complications, indicating that a distinct phosphorylation pattern of kinases in B cells identifies a clinically important subgroup of CVID patients
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a B cell
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| 650 |
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|a Cell signaling
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| 650 |
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4 |
|a Common variable immunodeficiency
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| 650 |
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|a Constitutive phosphorylation
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| 650 |
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4 |
|a Hierarchical clustering
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| 650 |
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|a Phospho-flow cytometry
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| 650 |
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7 |
|a Receptors, Antigen, B-Cell
|2 NLM
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| 650 |
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7 |
|a Phosphotransferases
|2 NLM
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| 650 |
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7 |
|a EC 2.7.-
|2 NLM
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| 700 |
1 |
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|a Aukrust, Pål
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jørgensen, Silje
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lingjærde, Ole Christian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Olweus, Johanna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Myklebust, June H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fevang, Børre
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 175(2017) vom: 01. Feb., Seite 69-74
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:175
|g year:2017
|g day:01
|g month:02
|g pages:69-74
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2016.11.014
|3 Volltext
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|d 175
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|h 69-74
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