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231224s2017 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-016-1743-6
|2 doi
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|a pubmed24n0887.xml
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|a (DE-627)NLM266372759
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|a (NLM)27866342
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Lee, Jiyun
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Phototoxicity and chronic toxicity of methyl paraben and 1,2-hexanediol in Daphnia magna
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|c 2017
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 02.03.2017
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Parabens are used as antimicrobial preservatives in consumer products. Exposure to methylparaben (MP) has been associated with adverse health outcomes, therefore, an alternative compound, 1,2-hexanediol (1,2-H), has been applied for cosmetics. In the present study, the phototoxicity of MP and 1,2-H, as well as the toxic effect caused by chronic exposure, were investigated using Daphnia magna. The 48 h acute toxicity tests with D. magna were conducted under indoor or ultraviolet (UV) light irradiation conditions, i.e., exposure to 4 h/d sunlight. Changes in the transcription of genes related to oxidative stress were determined in D. magna juveniles, to investigate the underlying mechanism of phototoxicity. The 21 d chronic toxicity tests of MP and 1,2-H were performed under indoor light irradiation. Exposure to MP under environmental level of UV light was more detrimental to D. magna. Transcripts of catalase and glutathione-S-transferase genes in D. magna was significantly increased by co-exposure to MP and UV light. After 21 d of chronic exposure to MP and 1,2-H, the reproduction no-observed effect concentrations for D. magna were 1 and >10 mg/L, respectively. The present study showed that exposure to UV could magnify the toxicity of MP on daphnids. Although acute and chronic toxicities of 1,2-H were generally lower than those of MP, its effects on other aquatic organisms should not be ignored. Further studies are needed to identify other mechanisms of MP phototoxicity
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|a Journal Article
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|a 1,2-hexanediol
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|a Daphnia magna
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|a Methyl paraben
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|a Phototoxicity
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|a Ultraviolet light
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| 650 |
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|a Cosmetics
|2 NLM
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|a Glycols
|2 NLM
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| 650 |
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|a Hexanes
|2 NLM
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| 650 |
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|a Parabens
|2 NLM
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| 650 |
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|a Water Pollutants, Chemical
|2 NLM
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| 650 |
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7 |
|a methylparaben
|2 NLM
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| 650 |
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7 |
|a A2I8C7HI9T
|2 NLM
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| 650 |
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7 |
|a 1,2-hexanediol
|2 NLM
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| 650 |
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7 |
|a TR046Y3K1G
|2 NLM
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| 700 |
1 |
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|a Park, Nayeon
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kho, Younglim
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lee, Kiyoung
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ji, Kyunghee
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 26(2017), 1 vom: 20. Jan., Seite 81-89
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
1 |
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|g volume:26
|g year:2017
|g number:1
|g day:20
|g month:01
|g pages:81-89
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| 856 |
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|u http://dx.doi.org/10.1007/s10646-016-1743-6
|3 Volltext
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|e 1
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|h 81-89
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