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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.10.017
|2 doi
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|a pubmed24n0886.xml
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|a (DE-627)NLM265964822
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|a (NLM)27818202
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|a (PII)S1521-6616(16)30151-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Huang, Xin
|e verfasserin
|4 aut
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|a The expression of Bcl-6 in circulating follicular helper-like T cells positively correlates with the disease activity in systemic lupus erythematosus
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 31.05.2017
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|a Date Revised 04.12.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016 Elsevier Inc. All rights reserved.
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|a Increased circulating follicular helper-like T cells (cTfh) are reported in systemic lupus erythematosus (SLE) patients. However, whether B-cell lymphoma 6 (Bcl-6) is expressed in cTfh cells remains to be clarified. In this study, we found that the frequencies of CD4+CXCR5hiPD-1hicTfh, CD4+CXCR5hiPD-1hiICOShi, and CD4+CXCR5hiPD-1hiBcl-6+ populations were significantly increased in SLE patients (n=70) when compared with healthy controls (n=48). Surprisingly, only CD4+CXCR5hiPD-1hiBcl-6+ cTfh cells, rather than CD4+CXCR5hiPD-1hi population, were positively correlated with SLEDAI and anti-dsDNA antibodies. An elevated level of IL-21 was found in SLE CD4+ T cells. Moreover, IL-21 promoted the enrichment of TET2 in Bcl-6 promoter region and induced Bcl-6 expression. Therefore, Bcl-6 expression in cTfh cells may represent a reliable marker for the disease activity in SLE
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|a Journal Article
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|a Bcl-6
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|a Disease activity
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|a IL-21
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|a SLE
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|a TET2
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|a cTfh
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|a BCL6 protein, human
|2 NLM
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|a DNA-Binding Proteins
|2 NLM
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|a Interleukins
|2 NLM
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|a Proto-Oncogene Proteins
|2 NLM
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|a Proto-Oncogene Proteins c-bcl-6
|2 NLM
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|a Dioxygenases
|2 NLM
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| 650 |
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|a EC 1.13.11.-
|2 NLM
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| 650 |
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|a TET2 protein, human
|2 NLM
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| 650 |
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|a EC 1.13.11.-
|2 NLM
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| 650 |
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|a interleukin-21
|2 NLM
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| 650 |
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|a MKM3CA6LT1
|2 NLM
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| 700 |
1 |
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|a Wu, Haijing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qiu, Hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Huilan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deng, Yaxiong
|e verfasserin
|4 aut
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| 700 |
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|a Zhao, Ming
|e verfasserin
|4 aut
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| 700 |
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|a Luo, Hairong
|e verfasserin
|4 aut
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| 700 |
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|a Zhou, Xiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Yubin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chan, Vera
|e verfasserin
|4 aut
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| 700 |
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|a Lau, Chak-Sing
|e verfasserin
|4 aut
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| 700 |
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|a Lu, Qianjin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 173(2016) vom: 02. Dez., Seite 161-170
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:173
|g year:2016
|g day:02
|g month:12
|g pages:161-170
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|u http://dx.doi.org/10.1016/j.clim.2016.10.017
|3 Volltext
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