Real time band selective F1 -decoupled proton NMR for the demixing of overlay spectra of chiral molecules
Copyright © 2016 John Wiley & Sons, Ltd.
| Publié dans: | Magnetic resonance in chemistry : MRC. - 1985. - 55(2017), 6 vom: 28. Juni, Seite 553-558 |
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| Auteur principal: | |
| Autres auteurs: | , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2017
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| Accès à la collection: | Magnetic resonance in chemistry : MRC |
| Sujets: | Journal Article Chiral discrimination Chiral liquid crystal Lanthanide shift reagent Pure shift NMR |
| Résumé: | Copyright © 2016 John Wiley & Sons, Ltd. The small chemical shift dispersion and complex multiplicity pattern in proton NMR limit quantifications, for instance the determination of enantiomeric excess (ee) for an enantiomeric mixture. Herein, we present a simple proton-proton correlation experiment with band selective homonuclear (BASH) decoupling in both F1 and F2 dimensions, for the removal of scalar and residual dipolar couplings to provide collapsed singlet for each chemical site. The method has been demonstrated to separate the severely overlapped spectra of enantiomers using both chiral isotropic and anisotropic phases as well as a small biomolecule, particularly for the diastereotopic protons and also for the determination of ee. Copyright © 2016 John Wiley & Sons, Ltd |
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| Description: | Date Completed 05.03.2018 Date Revised 05.03.2018 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.4547 |