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231224s2017 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1111/gcb.13548
|2 doi
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|a pubmed24n0886.xml
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|a (DE-627)NLM265888549
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|a (NLM)27809394
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Whilde, Jenny
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Precision wildlife medicine
|b applications of the human-centred precision medicine revolution to species conservation
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| 264 |
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|c 2017
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 23.10.2017
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|a Date Revised 02.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2016 John Wiley & Sons Ltd.
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|a The current species extinction crisis is being exacerbated by an increased rate of emergence of epizootic disease. Human-induced factors including habitat degradation, loss of biodiversity and wildlife population reductions resulting in reduced genetic variation are accelerating disease emergence. Novel, efficient and effective approaches are required to combat these epizootic events. Here, we present the case for the application of human precision medicine approaches to wildlife medicine in order to enhance species conservation efforts. We consider how the precision medicine revolution, coupled with the advances made in genomics, may provide a powerful and feasible approach to identifying and treating wildlife diseases in a targeted, effective and streamlined manner. A number of case studies of threatened species are presented which demonstrate the applicability of precision medicine to wildlife conservation, including sea turtles, amphibians and Tasmanian devils. These examples show how species conservation could be improved by using precision medicine techniques to determine novel treatments and management strategies for the specific medical conditions hampering efforts to restore population levels. Additionally, a precision medicine approach to wildlife health has in turn the potential to provide deeper insights into human health and the possibility of stemming and alleviating the impacts of zoonotic diseases. The integration of the currently emerging Precision Medicine Initiative with the concepts of EcoHealth (aiming for sustainable health of people, animals and ecosystems through transdisciplinary action research) and One Health (recognizing the intimate connection of humans, animal and ecosystem health and addressing a wide range of risks at the animal-human-ecosystem interface through a coordinated, collaborative, interdisciplinary approach) has great potential to deliver a deeper and broader interdisciplinary-based understanding of both wildlife and human diseases
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|a Journal Article
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| 650 |
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|a EcoHealth
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| 650 |
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|a One Health
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| 650 |
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4 |
|a chytridiomycosis
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| 650 |
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|a emerging disease
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| 650 |
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4 |
|a environmental DNA (eDNA)
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| 650 |
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4 |
|a epizootic disease
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| 650 |
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4 |
|a fibropapillomatosis
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| 650 |
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4 |
|a systems medicine
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| 650 |
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4 |
|a wildlife cancer
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| 650 |
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4 |
|a wildlife disease
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| 700 |
1 |
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|a Martindale, Mark Q
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Duffy, David J
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Global change biology
|d 1999
|g 23(2017), 5 vom: 21. Mai, Seite 1792-1805
|w (DE-627)NLM098239996
|x 1365-2486
|7 nnns
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| 773 |
1 |
8 |
|g volume:23
|g year:2017
|g number:5
|g day:21
|g month:05
|g pages:1792-1805
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1111/gcb.13548
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