A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model

A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model

Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 173(2016) vom: 09. Dez., Seite 10-18
1. Verfasser: Diesner, Susanne C (VerfasserIn)
Weitere Verfasser: Bergmayr, Cornelia, Pfitzner, Barbara, Assmann, Vera, Krishnamurthy, Durga, Starkl, Philipp, Endesfelder, David, Rothballer, Michael, Welzl, Gerhard, Rattei, Thomas, Eiwegger, Thomas, Szépfalusi, Zsolt, Fehrenbach, Heinz, Jensen-Jarolim, Erika, Hartmann, Anton, Pali-Schöll, Isabella, Untersmayr, Eva
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Allergen uptake Bacterial community composition Cytokines Food allergy Intestinal barrier function Microbiota Allergens Anti-Ulcer Agents Immunoglobulin A mehr... Immunoglobulin G Immunoglobulin E 37341-29-0 Sucralfate 54182-58-0 Ovalbumin 9006-59-1
Beschreibung
Zusammenfassung:Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
In our mouse model, gastric acid-suppression is associated with antigen-specific IgE and anaphylaxis development. We repeatedly observed non-responder animals protected from food allergy. Here, we aimed to analyse reasons for this protection. Ten out of 64 mice, subjected to oral ovalbumin (OVA) immunizations under gastric acid-suppression, were non-responders without OVA-specific IgE or IgG1 elevation, indicating protection from allergy. In these non-responders, allergen challenges confirmed reduced antigen uptake and lack of anaphylactic symptoms, while in allergic mice high levels of mouse mast-cell protease-1 and a body temperature reduction, indicative for anaphylaxis, were determined. Upon OVA stimulation, significantly lower IL-4, IL-5, IL-10 and IL-13 levels were detected in non-responders, while IL-22 was significantly higher. Comparison of fecal microbiota revealed differences of bacterial communities on single bacterial Operational-Taxonomic-Unit level between the groups, indicating protection from food allergy being associated with a distinct microbiota composition in a non-responding phenotype in this mouse model
Beschreibung:Date Completed 31.05.2017
Date Revised 01.06.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2016.10.009