Targeted Raman Imaging of Cells Using Graphene Oxide-Based Hybrids

Graphene oxide (GO) is a reliable and multifunctional platform to perform cell imaging. In this work, a controllable Pt-seed-mediated method is used to prepare GO/gold nanoparticle (AuNP) hybrids, and after the covalent binding of folic acid (FA), GO/AuNP/FA hybrids are prepared. Selective labeling...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 32(2016), 40 vom: 11. Okt., Seite 10253-10258
1. Verfasser: Zhang, Zhenyu (VerfasserIn)
Weitere Verfasser: Wang, Meng, Gao, Dongliang, Luo, Da, Liu, Qinghai, Yang, Juan, Li, Yan
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2016
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Folate Receptors, GPI-Anchored Oxides Thioglycolates Gold 7440-57-5 Graphite 7782-42-5 2-mercaptoacetate mehr... 7857H94KHM Folic Acid 935E97BOY8
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520 |a Graphene oxide (GO) is a reliable and multifunctional platform to perform cell imaging. In this work, a controllable Pt-seed-mediated method is used to prepare GO/gold nanoparticle (AuNP) hybrids, and after the covalent binding of folic acid (FA), GO/AuNP/FA hybrids are prepared. Selective labeling and Raman imaging of folate receptor (FR)-positive HeLa cells are realized using such GO-based hybrids. In this system, FA is the targeting agent, AuNPs work as surface-enhanced Raman scattering substrates, and GO takes the role of both supporting the AuNPs with FA and acting as a Raman probe. This research further extends the application of GO as a multifunctional platform in bioimaging and other biomedical processes 
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700 1 |a Wang, Meng  |e verfasserin  |4 aut 
700 1 |a Gao, Dongliang  |e verfasserin  |4 aut 
700 1 |a Luo, Da  |e verfasserin  |4 aut 
700 1 |a Liu, Qinghai  |e verfasserin  |4 aut 
700 1 |a Yang, Juan  |e verfasserin  |4 aut 
700 1 |a Li, Yan  |e verfasserin  |4 aut 
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