Targeted Raman Imaging of Cells Using Graphene Oxide-Based Hybrids
Graphene oxide (GO) is a reliable and multifunctional platform to perform cell imaging. In this work, a controllable Pt-seed-mediated method is used to prepare GO/gold nanoparticle (AuNP) hybrids, and after the covalent binding of folic acid (FA), GO/AuNP/FA hybrids are prepared. Selective labeling...
| Publié dans: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 32(2016), 40 vom: 11. Okt., Seite 10253-10258 |
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| Auteur principal: | |
| Autres auteurs: | , , , , , |
| Format: | Article en ligne |
| Langue: | English |
| Publié: |
2016
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| Accès à la collection: | Langmuir : the ACS journal of surfaces and colloids |
| Sujets: | Journal Article Research Support, Non-U.S. Gov't Folate Receptors, GPI-Anchored Oxides Thioglycolates Gold 7440-57-5 Graphite 7782-42-5 2-mercaptoacetate plus... |
| Résumé: | Graphene oxide (GO) is a reliable and multifunctional platform to perform cell imaging. In this work, a controllable Pt-seed-mediated method is used to prepare GO/gold nanoparticle (AuNP) hybrids, and after the covalent binding of folic acid (FA), GO/AuNP/FA hybrids are prepared. Selective labeling and Raman imaging of folate receptor (FR)-positive HeLa cells are realized using such GO-based hybrids. In this system, FA is the targeting agent, AuNPs work as surface-enhanced Raman scattering substrates, and GO takes the role of both supporting the AuNPs with FA and acting as a Raman probe. This research further extends the application of GO as a multifunctional platform in bioimaging and other biomedical processes |
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| Description: | Date Completed 21.06.2018 Date Revised 21.06.2018 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1520-5827 |