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|e rakwb
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|a eng
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|a Pawar, Vidya
|e verfasserin
|4 aut
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|a A novel family of plant nuclear envelope-associated proteins
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 20.11.2017
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|a Date Revised 13.01.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © The Author 2016. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
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|a This paper describes the characterisation of a new family of higher plant nuclear envelope-associated proteins (NEAPs) that interact with other proteins of the nuclear envelope. In the model plant Arabidopsis thaliana, the family consists of three genes expressed ubiquitously (AtNEAP1-3) and a pseudogene (AtNEAP4). NEAPs consist of extensive coiled-coil domains, followed by a nuclear localisation signal and a C-terminal predicted transmembrane domain. Domain deletion mutants confirm the presence of a functional nuclear localisation signal and transmembrane domain. AtNEAP proteins localise to the nuclear periphery as part of stable protein complexes, are able to form homo- and heteromers, and interact with the SUN domain proteins AtSUN1 and AtSUN2, involved in the linker of nucleoskeleton and cytoskeleton (LINC) complex. An A. thaliana cDNA library screen identified a putative transcription factor called AtbZIP18 as a novel interactor of AtNEAP1, which suggest a connection between NEAP and chromatin. An Atneap1 Atneap3 double-knockout mutant showed reduced root growth, and altered nuclear morphology and chromatin structure. Thus AtNEAPs are suggested as inner nuclear membrane-anchored coiled-coil proteins with roles in maintaining nuclear morphology and chromatin structure
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Arabidopsis thaliana
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|a LINC complex
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|a chromatin
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|a higher plant
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|a inner nuclear membrane
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|a nuclear envelope
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|a nuclear lamina
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|a nucleoskeleton
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|a nucleus.
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|a Arabidopsis Proteins
|2 NLM
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|a Chromatin
|2 NLM
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|a Membrane Proteins
|2 NLM
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| 700 |
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|a Poulet, Axel
|e verfasserin
|4 aut
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|a Détourné, Gwénaëlle
|e verfasserin
|4 aut
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| 700 |
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|a Tatout, Christophe
|e verfasserin
|4 aut
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| 700 |
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|a Vanrobays, Emmanuel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Evans, David E
|e verfasserin
|4 aut
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| 700 |
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|a Graumann, Katja
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 67(2016), 19 vom: 15. Okt., Seite 5699-5710
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|x 1460-2431
|7 nnns
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| 773 |
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|g volume:67
|g year:2016
|g number:19
|g day:15
|g month:10
|g pages:5699-5710
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