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231224s2016 xx |||||o 00| ||eng c |
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|a pubmed24n0880.xml
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|a (NLM)27605308
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Kumal, Raju R
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Plasmon-Enhanced Photocleaving Dynamics in Colloidal MicroRNA-Functionalized Silver Nanoparticles Monitored with Second Harmonic Generation
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| 264 |
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|c 2016
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 21.06.2018
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|a Date Revised 13.11.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The photocleaving dynamics of colloidal microRNA-functionalized nanoparticles are studied using time-dependent second harmonic generation (SHG) measurements. Model drug-delivery systems composed of oligonucleotides attached to either silver nanoparticles or polystyrene nanoparticles using a nitrobenzyl photocleavable linker are prepared and characterized. The photoactivated controlled release is observed to be most efficient on resonance at 365 nm irradiation, with pseudo-first-order rate constants that are linearly proportional to irradiation powers. Additionally, silver nanoparticles show a 6-fold plasmon enhancement in photocleaving efficiency over corresponding polystyrene nanoparticle rates, while our previous measurements on gold nanoparticles show a 2-fold plasmon enhancement compared to polystyrene nanoparticles. Characterizations including extinction spectroscopy, electrophoretic mobility, and fluorimetry measurements confirm the analysis from the SHG results. The real-time SHG measurements are shown to be a highly sensitive method for investigating plasmon-enhanced photocleaving dynamics in model drug delivery systems
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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7 |
|a Drug Carriers
|2 NLM
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| 650 |
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7 |
|a MicroRNAs
|2 NLM
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| 650 |
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7 |
|a Polystyrenes
|2 NLM
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| 650 |
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7 |
|a Silver
|2 NLM
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| 650 |
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7 |
|a 3M4G523W1G
|2 NLM
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| 700 |
1 |
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|a Abu-Laban, Mohammad
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Landry, Corey R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kruger, Blake
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Zhenyu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hayes, Daniel J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Haber, Louis H
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 32(2016), 40 vom: 11. Okt., Seite 10394-10401
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:32
|g year:2016
|g number:40
|g day:11
|g month:10
|g pages:10394-10401
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