|
|
|
|
LEADER |
01000naa a22002652 4500 |
001 |
NLM263881903 |
003 |
DE-627 |
005 |
20231224204851.0 |
007 |
cr uuu---uuuuu |
008 |
231224s2017 xx |||||o 00| ||eng c |
024 |
7 |
|
|a 10.1002/mrc.4508
|2 doi
|
028 |
5 |
2 |
|a pubmed24n0879.xml
|
035 |
|
|
|a (DE-627)NLM263881903
|
035 |
|
|
|a (NLM)27575369
|
040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
041 |
|
|
|a eng
|
100 |
1 |
|
|a Naumczuk, Beata
|e verfasserin
|4 aut
|
245 |
1 |
0 |
|a Preliminary study of mechanism of action of SN38 derivatives. Physicochemical data, evidence of interaction and alkylation of DNA octamer d(GCGATCGC)2
|
264 |
|
1 |
|c 2017
|
336 |
|
|
|a Text
|b txt
|2 rdacontent
|
337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
500 |
|
|
|a Date Completed 06.04.2018
|
500 |
|
|
|a Date Revised 02.12.2018
|
500 |
|
|
|a published: Print-Electronic
|
500 |
|
|
|a Citation Status MEDLINE
|
520 |
|
|
|a Copyright © 2016 John Wiley & Sons, Ltd.
|
520 |
|
|
|a The synthesis of water-soluble SN38 derivatives is presented, and their stability in solutions used during drug development studies has been investigated. A preliminary study of mechanism of action of 9-aminomethyl SN38 is presented. Using NMR techniques, the interaction of the oligomer d(GCGATCGC)2 is studied, showing that the terminal GC base pairs are the main site of interaction. Using pulsed field gradient spin echo and mass spectroscopy, evidence of a spontaneous alkylation reaction of the DNA oligomer with SN38 derivatives is presented. A proposed mechanism of reaction is suggested. Copyright © 2016 John Wiley & Sons, Ltd
|
650 |
|
4 |
|a Journal Article
|
650 |
|
4 |
|a DNA
|
650 |
|
4 |
|a MALDI MS
|
650 |
|
4 |
|a NMR
|
650 |
|
4 |
|a SN38 derivative
|
650 |
|
4 |
|a covalent binding
|
650 |
|
7 |
|a Antineoplastic Agents
|2 NLM
|
650 |
|
7 |
|a Polydeoxyribonucleotides
|2 NLM
|
650 |
|
7 |
|a Irinotecan
|2 NLM
|
650 |
|
7 |
|a 7673326042
|2 NLM
|
650 |
|
7 |
|a DNA
|2 NLM
|
650 |
|
7 |
|a 9007-49-2
|2 NLM
|
650 |
|
7 |
|a Camptothecin
|2 NLM
|
650 |
|
7 |
|a XT3Z54Z28A
|2 NLM
|
700 |
1 |
|
|a Kawęcki, Robert
|e verfasserin
|4 aut
|
700 |
1 |
|
|a Bocian, Wojciech
|e verfasserin
|4 aut
|
700 |
1 |
|
|a Bednarek, Elżbieta
|e verfasserin
|4 aut
|
700 |
1 |
|
|a Sitkowski, Jerzy
|e verfasserin
|4 aut
|
700 |
1 |
|
|a Kozerski, Lech
|e verfasserin
|4 aut
|
773 |
0 |
8 |
|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 55(2017), 2 vom: 15. Feb., Seite 128-136
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
|
773 |
1 |
8 |
|g volume:55
|g year:2017
|g number:2
|g day:15
|g month:02
|g pages:128-136
|
856 |
4 |
0 |
|u http://dx.doi.org/10.1002/mrc.4508
|3 Volltext
|
912 |
|
|
|a GBV_USEFLAG_A
|
912 |
|
|
|a SYSFLAG_A
|
912 |
|
|
|a GBV_NLM
|
912 |
|
|
|a GBV_ILN_350
|
951 |
|
|
|a AR
|
952 |
|
|
|d 55
|j 2017
|e 2
|b 15
|c 02
|h 128-136
|