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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.6b01925
|2 doi
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|a pubmed24n0877.xml
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|a (NLM)27501777
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Tokudome, Yasuaki
|e verfasserin
|4 aut
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| 245 |
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|a High-Density Protein Loading on Hierarchically Porous Layered Double Hydroxide Composites with a Rational Mesostructure
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.06.2018
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|a Date Revised 07.06.2018
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Hierarchically porous biocompatible Mg-Al-Cl-type layered double hydroxide (LDH) composites containing aluminum hydroxide (Alhy) have been prepared using a phase-separation process. The sol-gel synthesis allows for the hierarchical pores of the LDH-Alhy composites to be tuned, leading to a high specific solid surface area per unit volume available for high-molecular-weight protein adsorptions. A linear relationship between the effective surface area, SEFF, and loading capacity of a model protein, bovine serum albumin (BSA), is established following successful control of the structure of the LDH-Alhy composite. The threshold of the mean pore diameter, Dpm, above which BSA is effectively adsorbed on the surface of LDH-Alhy composites, is deduced as 20 nm. In particular, LDH-Alhy composite aerogels obtained via supercritical drying exhibit an extremely high capacity for protein loading (996 mg/g) as a result of a large mean mesopore diameter (>30 nm). The protein loading on LDH-Alhy is >14 times that of a reference LDH material (70 mg/g) prepared via a standard procedure. Importantly, BSA molecules pre-adsorbed on porous composites were successfully released on soaking in ionic solutions (HPO4(2-) and Cl(-) aqueous). The superior capability of the biocompatible LDH materials for loading, encapsulation, and releasing large quantities of proteins was clearly demonstrated
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Fukui, Megu
|e verfasserin
|4 aut
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1 |
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|a Tarutani, Naoki
|e verfasserin
|4 aut
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|a Nishimura, Sari
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Prevot, Vanessa
|e verfasserin
|4 aut
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|a Forano, Claude
|e verfasserin
|4 aut
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|a Poologasundarampillai, Gowsihan
|e verfasserin
|4 aut
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|a Lee, Peter D
|e verfasserin
|4 aut
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| 700 |
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|a Takahashi, Masahide
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 32(2016), 35 vom: 06. Sept., Seite 8826-33
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:32
|g year:2016
|g number:35
|g day:06
|g month:09
|g pages:8826-33
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|u http://dx.doi.org/10.1021/acs.langmuir.6b01925
|3 Volltext
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