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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.08.004
|2 doi
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|a pubmed25n0877.xml
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|a (NLM)27498109
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|a (PII)S1521-6616(16)30262-5
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|a DE-627
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|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Qiao, Yong-Chao
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Changes of regulatory T cells, transforming growth factor-beta and interleukin-10 in patients with type 1 diabetes mellitus
|b A systematic review and meta-analysis
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 30.03.2017
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|a Date Revised 02.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016 Elsevier Inc. All rights reserved.
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|a Regulatory T lymphocyte cells (Treg) associated with interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) have implicated in the development of type 1 diabetes mellitus (T1DM), yet the existing evidence remains unclear. Hereby we performed a systematic review and meta-analysis to characterize the changes in T1DM patients. A total of 1407 T1DM patients and 1373 healthy controls from 40 case-control studies were eventually included in the pooling analysis. Compared with the controls, T1DM patients had decreased frequency of CD4(+)CD25(+)Treg (p=0.0003), CD4(+)CD25(+)Foxp3(+)Treg (p=0.020), and the level of TGF-β (p=0.030). Decrease in IL-10 (p=0.14) was not significant. All the changes remained significant when the studies with low NOS scores and publication bias were excluded. In conclusion, peripheral Treg and serum TGF-β are reduced in type 1 diabetes mellitus whereas changes in serum IL-10 are not significant
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|a Journal Article
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|a Meta-Analysis
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Review
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| 650 |
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|a Systematic Review
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| 650 |
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|a Interleukin-10
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| 650 |
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|a Meta-analysis
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| 650 |
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|a Regulatory T cells
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| 650 |
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|a Transforming growth factor-β
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| 650 |
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|a Type 1 diabetes mellitus
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| 650 |
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|a FOXP3 protein, human
|2 NLM
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| 650 |
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|a Forkhead Transcription Factors
|2 NLM
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| 650 |
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|a Interleukin-2 Receptor alpha Subunit
|2 NLM
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| 650 |
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|a Transforming Growth Factor beta
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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|a 130068-27-8
|2 NLM
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| 700 |
1 |
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|a Shen, Jian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hong, Xue-Zhi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liang, Ling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bo, Chao-Sheng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sui, Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Hai-Lu
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 170(2016) vom: 15. Sept., Seite 61-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:170
|g year:2016
|g day:15
|g month:09
|g pages:61-9
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2016.08.004
|3 Volltext
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