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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2016.07.025
|2 doi
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|a pubmed24n0877.xml
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|a (DE-627)NLM26318336X
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|a (NLM)27497628
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|a (PII)S1521-6616(16)30250-9
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Jansen, Anne
|e verfasserin
|4 aut
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|a Prognosis of Good syndrome
|b mortality and morbidity of thymoma associated immunodeficiency in perspective
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|c 2016
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 31.05.2017
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|a Date Revised 08.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
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|a Good syndrome (GS) or thymoma-associated immunodeficiency, is a rare condition that has only been studied in retrospective case series. General consensus was that GS has a worse prognosis than other humoral immunodeficiencies. In this study, physicians of GS patients completed two questionnaires with a two year interval with data on 47 patients, 499 patient years in total. Results on epidemiology, disease characteristics, and outcome are presented. Mean age at diagnosis was 60years and median follow-up from onset of symptoms was 9years. There was a high frequency of respiratory tract infections due to encapsulated bacteria. Median survival was 14years. Survival was reduced compared to age-matched population controls (5-year survival: 82% versus 95%, p=0.008). In this cohort survival was not associated with gender (HR 0.9, 95% CI 0.3-3.0), autoimmune diseases (HR 2.9, 95% CI 0.8-10.1) or immunosuppressive use (HR 0.3, 95% CI: 0.1-1.2)
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|a Journal Article
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|a Good syndrome
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| 650 |
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|a Immunodeficiency
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| 650 |
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|a Infection
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| 650 |
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4 |
|a Thymoma
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| 700 |
1 |
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|a van Deuren, Marcel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Miller, Joanne
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Litzman, Jiri
|e verfasserin
|4 aut
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| 700 |
1 |
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|a de Gracia, Javier
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sáenz-Cuesta, Matías
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Szaflarska, Anna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Martelius, Timi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Takiguchi, Yuichi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Patel, Smita
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Misbah, Siraj
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Simon, Anna
|e verfasserin
|4 aut
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| 700 |
0 |
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|a Good syndrome Study Group
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 171(2016) vom: 01. Okt., Seite 12-17
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:171
|g year:2016
|g day:01
|g month:10
|g pages:12-17
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|u http://dx.doi.org/10.1016/j.clim.2016.07.025
|3 Volltext
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