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231224s2016 xx |||||o 00| ||eng c |
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|a 10.1111/vcp.12387
|2 doi
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|a pubmed24n0876.xml
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|a (DE-627)NLM263044394
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|a (NLM)27483044
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hergt, Franziska
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Use of a 2-tier histologic grading system for canine cutaneous mast cell tumors on cytology specimens
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1 |
|c 2016
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 07.03.2018
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|a Date Revised 02.12.2018
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|a published: Print-Electronic
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|a CommentIn: Vet Clin Pathol. 2016 Dec;45(4):531. - PMID 27716984
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|a Citation Status MEDLINE
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|a © 2016 American Society for Veterinary Clinical Pathology.
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|a BACKGROUND: Mast cell tumors (MCT) represent the most common malignant skin tumor in the dog. Diagnosis of an MCT can be achieved through cytologic examination of a fine-needle aspirate. However, the grade of the tumor is an important prognostic marker and currently requires histologic assessment. Recently a 2-tier histologic grading system based on nuclear features including number of mitoses, multinucleated cells, bizarre nuclei, and karyomegaly was proposed
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|a OBJECTIVES: The aim of this study was to assess if the cytomorphologic criteria proposed in the 2-tier histologic grading system are applicable to cytology specimens
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|a METHODS: A total of 141 MCT specimens reported as grade I, II, or III according to the Patnaik system with both histologic specimens and fine-needle aspirates available were histologically and cytologically reevaluated in a retrospective study
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|a RESULTS: According to the 2-tier grading system, 38 cases were diagnosed histologically as high-grade and 103 as low-grade MCT. Cytologic grading resulted in 36 high-grade and 105 low-grade tumors. Agreement between histologic and cytologic grading based on the 2-tier grading system was achieved in 133 cases (sensitivity 86.8%, specificity 97.1%, kappa value 0.853), but 5 high-grade tumors on histology were classified as low-grade on cytology
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|a CONCLUSION: Cytologic grading of MCT in the dog is helpful for initial assessment. However, the reliability of cytology using the 2-tier grading system is considered inadequate at this point. Prospective studies including clinical outcome should be pursued to further determine diagnostic accuracy of cytologic mast cell grading
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|a Journal Article
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|a Cytomorphologic criteria
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|a dog
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|a fine-needle aspirates
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4 |
|a nuclear abnormalities
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| 700 |
1 |
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|a von Bomhard, Wolf
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kent, Michael S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hirschberger, Johannes
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 45(2016), 3 vom: 19. Sept., Seite 477-83
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnns
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| 773 |
1 |
8 |
|g volume:45
|g year:2016
|g number:3
|g day:19
|g month:09
|g pages:477-83
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4 |
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|u http://dx.doi.org/10.1111/vcp.12387
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